ArticleInternational journal of chronic obstructive pulmonary disease2017
Bronchiectasis and increased risk of ischemic stroke: a nationwide population-based cohort study.
Article in International journal of chronic obstructive pulmonary disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- A systematic literature review of the clinical and socioeconomic burden of bronchiectasis.European respiratory review : an official journal of the European Respiratory Society · 2024Pooled it
- Exploring the molecular mechanism of apigenin in treating bronchiectasis based on network pharmacology and molecular docking.Scientific reports · 2025Article
- The impact of cardiovascular events in bronchiectasis: a systematic review and meta-analysis.ERJ open research · 2024Article
- Association of the MMP-9 polymorphism and ischemic stroke risk in southern Chinese Han population.BMC neurology · 2019Article
- Effect of Bronchodilator and Steroid Use on Heart Disease and Stroke Risks in a Bronchiectasis-Chronic Obstructive Pulmonary Disease Overlap Cohort: A Propensity Score Matching Study.Frontiers in pharmacology · 2019Article
- Pulmonary vascular pruning in smokers with bronchiectasis.ERJ open research · 2018Article
- Arterial stiffness in adults with steady-state bronchiectasis: association with clinical indices and disease severity.Respiratory research · 2018Article
- Design of a Clinical Decision Support System for Fracture Prediction Using Imbalanced Dataset.Journal of healthcare engineering · 2018Article
- Neurological and Sleep Disturbances in Bronchiectasis.Journal of clinical medicine · 2017Review
- Association between non-cystic fibrosis bronchiectasis and the risk of incident dementia: A nationwide cohort study.Chronic respiratory diseaseArticle
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBronchiectasis is characterized by permanent dilatation of the bronchial tree caused by recurrent airway infection and inflammation. The association of atherosclerosis and inflammation is well established. However, studies on the relationship between bronchiectasis and stroke are scant.
objectiveWe conducted a population-based cohort study to investigate the incidence and risk of ischemic stroke in patients with bronchiectasis.
methodsData of 1,295 patients newly diagnosed as bronchiectasis between 2000 and 2008 were retrieved from the Taiwan National Health Insurance Research Database. A total of 6,475 controls without bronchiectasis at a ratio of 5:1 were randomly selected from the general population based on frequency-matched age and sex to the patients. All participants were followed up to the date of ischemic stroke development, censoring, or the end of 2010. The Cox proportional hazard model was used to identify the risk of ischemic stroke in patients with bronchiectasis compared with those without bronchiectasis.
resultsThe patients with bronchiectasis exhibited a higher incidence rate of ischemic stroke (9.18 vs 4.66 per 1,000 person-years) than the patients without bronchiectasis, with an adjusted hazard ratio of 1.74 (95% confidence interval =1.28-2.35). The patients with bronchiectasis and any comorbidities exhibited a 2.66-fold adjusted hazard ratio of ischemic stroke compared with those with neither bronchiectasis nor comorbidity (95% confidence interval =1.85-3.84). The patients with bronchiectasis carried a dose response of ischemic stroke according to the number of emergency visits and hospitalizations per year.
conclusionThis study indicated that bronchiectasis is an independent risk factor of ischemic stroke.
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