ReviewClinical interventions in aging2017
Common methods of biological age estimation.
Review in Clinical interventions in aging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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Who cites it
71 citing papers in PubMed.
- Exercise and epigenetic ages in older adults with myeloid malignancies.European journal of medical research · 2023Trial
- Effect of Diet, Exercise, or Both on Biological Age and Healthy Aging in Older Adults with Obesity: Secondary Analysis of a Randomized Controlled Trial.The journal of nutrition, health & aging · 2022Trial
- Facial skin aging: an integrative analysis of genetics, epigenetics, and lifestyle factors.GeroScience · 2026Article
- Biological aging, circulating lipid biomarkers and pancreatic diseases: a prospective cohort study based on the UK Biobank.The journal of nutrition, health & aging · 2026Article
- Functional, molecular, and digital measurements of biological age.The Journal of clinical investigation · 2026Review
- OLD DOG - Validating the dog as an animal model for human aging studies.The Journal of frailty & aging · 2026Article
- Estimating Vascular Age to Evaluate the Association Between Aging and Cardiovascular Disease.Aging cell · 2026Article
- Frailty Among the Older Adults in Bangladesh: A Comparative Analysis of Rural and Urban Populations.Health science reports · 2026Article
- Association of Edentulism With Subsequent Biological Age: A Cohort Study.Journal of clinical periodontology · 2026Article
- Cultural Engagement Is Related to Decelerated Physiological Age: Doubly Robust Estimations in a National Cohort Study.Annals of the New York Academy of Sciences · 2026Article
- Acute biological age as a determinant of adverse outcomes requiring hospitalization in Danish emergency department patients.Communications medicine · 2026Article
- CardioMetAge estimates cardiometabolic aging and predicts disease outcomes.BMC medicine · 2026Article
- Social connections are differentially related to subjective age and physiological age acceleration amongst older adults.Nature communications · 2026Article
- Association Between Neutrophil Percentage-Albumin Ratio and Biological Aging in Rheumatoid Arthritis in the United States: A Cross-Sectional Study of NHANES.Mediators of inflammation · 2026Article
- Associations of physical activity domains and delayed biological aging: assessing heterogeneity and interaction of effects.Biology of sport · 2026Article
- Association of biological age acceleration with cardiovascular disease and premature mortality: a population-based prospective cohort study.Frontiers in public health · 2026Article
- Targeting biological age with bioactive, microbiota-accessible nutritional complexes: a pilot study on healthspan extension in medically healthy adults.Scientific reports · 2025Article
- Assessment of Cervical Vertebral Maturation and Chronological Age in Yemeni Children and Adolescents Using Lateral Cephalometric Radiographs.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- A simple blood biomarker based on gene expression describes cardiovascular health-related biological age.GeroScience · 2025Article
- Association of new Life's Essential 8 with biological aging among the national health and nutrition examination surveys.Scientific reports · 2025Article
11 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
At present, no single indicator could be used as a golden index to estimate aging process. The biological age (BA), which combines several important biomarkers with mathematical modeling, has been proposed for >50 years as an aging estimation method to replace chronological age (CA). The common methods used for BA estimation include the multiple linear regression (MLR), the principal component analysis (PCA), the Hochschild's method, and the Klemera and Doubal's method (KDM). The fundamental differences in these four methods are the roles of CA and the selection criteria of aging biomarkers. In MLR and PCA, CA is treated as the selection criterion and an independent index. The Hochschild's method and KDM share a similar concept, making CA an independent variable. Previous studies have either simply constructed the BA model by one or compared the four methods together. However, reviews have yet to illustrate and compare the four methods systematically. Since the BA model is a potential estimation of aging for clinical use, such as predicting onset and prognosis of diseases, improving the elderly's living qualities, and realizing successful aging, here we summarize previous BA studies, illustrate the basic statistical steps, and thoroughly discuss the comparisons among the four common BA estimation methods.
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