Evidence map›Paper›PMID 28546566›Full record

ArticleScientific reports2017

A diastereoselective synthesis of Cebranopadol, a novel analgesic showing NOP/mu mixed agonism.

Anna Fantinati, Sara Bianco, Remo Guerrini, Severo Salvadori, Salvatore Pacifico, Maria Camilla Cerlesi, Girolamo Calo, Claudio Trapella

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anna FantinatiDepartment of Chemical and Pharmaceutical Sciences and LTTA, University of Ferrara, 44121, Ferrara, Italy.
Sara BiancoDepartment of Chemical and Pharmaceutical Sciences and LTTA, University of Ferrara, 44121, Ferrara, Italy.
Remo GuerriniDepartment of Chemical and Pharmaceutical Sciences and LTTA, University of Ferrara, 44121, Ferrara, Italy.
Severo SalvadoriDepartment of Chemical and Pharmaceutical Sciences and LTTA, University of Ferrara, 44121, Ferrara, Italy.
Salvatore PacificoDepartment of Chemical and Pharmaceutical Sciences and LTTA, University of Ferrara, 44121, Ferrara, Italy.
Maria Camilla CerlesiDepartment of Medical Sciences, Section of Pharmacology and National Institute of Neuroscience, University of Ferrara, 44121, Ferrara, Italy.
Girolamo CaloDepartment of Medical Sciences, Section of Pharmacology and National Institute of Neuroscience, University of Ferrara, 44121, Ferrara, Italy.
Claudio TrapellaDepartment of Chemical and Pharmaceutical Sciences and LTTA, University of Ferrara, 44121, Ferrara, Italy. trap@unife.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A diastereoselective synthesis of the title compound as a single E diastereomer has been efficiently accomplished by assembling the featured pyrano-indole scaffold of the spiro[cyclohexane-dihydropyrano[3,4-b]-indole]-amine framework through an oxa-Pictet-Spengler reaction, promoted by a cheap and green Zeolite catalyst. Basic pharmacological experiments demonstrate that Cebranopadol acts as a mixed nociception/orphanin FQ (NOP) and mu (MOP) opioid receptor agonist useful for treatment of chronic pain.

Indexed as

AnalgesicsChemistry Techniques, SyntheticChromatography, LiquidIndolesMass SpectrometryNociceptin ReceptorReceptors, OpioidReceptors, Opioid, muSpiro Compounds6'-fluoro-4',9'-dihydro-N,N-dimethyl-4-phenylspiro(cyclohexane-1,1'(3'H)-pyrano(3,4-b)indol)-4-amineAnalgesicsIndolesNociceptin ReceptorReceptors, OpioidReceptors, Opioid, muSpiro Compounds

Identifiers

PMID28546566
PMCPMC5445067

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.