Evidence map›Paper›PMID 28546505›Full record

ArticleDrug metabolism and disposition: the biological fate of chemicals2017

Role of CYP2B in Phenobarbital-Induced Hepatocyte Proliferation in Mice.

Lei Li, Xiaochen Bao, Qing-Yu Zhang, Masahiko Negishi, Xinxin Ding

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug metabolism and disposition: the biological fate of chemicals, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  4. Review
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Lei LiCollege of Nanoscale Science, SUNY Polytechnic Institute, Albany, New York (L.L., X.D.); Wadsworth Center, New York State Department of Health, and School of Public Health, University at Albany, Albany, New York (L.L., X.B., Q.Z., X.D.); and National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina (M.N.).
Xiaochen BaoCollege of Nanoscale Science, SUNY Polytechnic Institute, Albany, New York (L.L., X.D.); Wadsworth Center, New York State Department of Health, and School of Public Health, University at Albany, Albany, New York (L.L., X.B., Q.Z., X.D.); and National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina (M.N.).
Qing-Yu ZhangCollege of Nanoscale Science, SUNY Polytechnic Institute, Albany, New York (L.L., X.D.); Wadsworth Center, New York State Department of Health, and School of Public Health, University at Albany, Albany, New York (L.L., X.B., Q.Z., X.D.); and National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina (M.N.).
Masahiko NegishiCollege of Nanoscale Science, SUNY Polytechnic Institute, Albany, New York (L.L., X.D.); Wadsworth Center, New York State Department of Health, and School of Public Health, University at Albany, Albany, New York (L.L., X.B., Q.Z., X.D.); and National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina (M.N.).
Xinxin DingCollege of Nanoscale Science, SUNY Polytechnic Institute, Albany, New York (L.L., X.D.); Wadsworth Center, New York State Department of Health, and School of Public Health, University at Albany, Albany, New York (L.L., X.B., Q.Z., X.D.); and National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina (M.N.) xding@sunypoly.edu.
New York State Department of Health · USSUNY Polytechnic Institute · USWadsworth Center · US

Funding

Mechanisms and biological consequences of the nuclear receptor CAR activationZIAES080040 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI NEGISHI, MASAHIKO · 2009 to 2020
$35.3M
Metabolic Mechanisms of Naphthalene Toxicity in LungR01ES020867 · NIEHS · WADSWORTH CENTER · PI Xinxin Ding, Laura S Van Winkle · 2013 to 2026
$6.4M
Human CYP2A and respiratory tract xenobiotic toxicityR01CA092596 · NCI · WADSWORTH CENTER · PI DING, XINXIN · 2003 to 2020
$6.1M
Intestinal P450 and Xenobiotic MetabolismR01GM082978 · NIGMS · WADSWORTH CENTER · PI ZHANG, QING-YU · 2008 to 2018
$3.3M
NCI NIH HHS R01 CA092596NIEHS NIH HHS R01 ES020867NIGMS NIH HHS R01 GM082978
6 · The paper itself

Abstract

Phenobarbital (PB) promotes liver tumorigenesis in rodents, in part through activation of the constitutive androstane receptor (CAR) and the consequent changes in hepatic gene expression and increases in hepatocyte proliferation. A typical effect of CAR activation by PB is a marked induction of

Indexed as

AnimalsAryl Hydrocarbon HydroxylasesCell ProliferationCytochrome P450 Family 2Enzyme InductionFemaleHepatocytesHypnotics and SedativesMaleMiceMice, Inbred C57BLMice, KnockoutPhenobarbitalSteroid HydroxylasesAryl Hydrocarbon HydroxylasesCyp2b10 protein, mouseCytochrome P450 Family 2Hypnotics and SedativesPhenobarbitalsteroid hormone 7-alpha-hydroxylaseSteroid Hydroxylases

Identifiers

PMID28546505
PMCPMC5518717
OpenAlexW2618369152

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.