ArticleJournal of the American Heart Association2017
Electrocardiographic Predictors of Heart Failure With Reduced Versus Preserved Ejection Fraction: The Multi-Ethnic Study of Atherosclerosis.
Article in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06699056 (AI-Enabled Direct-from-ECG Ejection Fraction), which is not on this map. Cited by 43 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
AI-Enabled Direct-from-ECG Ejection Fraction (EF) Severity Using COR ECG Wearable Monitor
Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- Electrocardiographic characteristics in patients with heart failure and normal ejection fraction: A systematic review and meta-analysis.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2020Pooled it
- Within a Heartbeat: A Machine Learning Approach Using VCG for Heart Failure Assessment in Sinus Rhythm.Journal of personalized medicine · 2026Article
- Article
- Isolated non-specific electrocardiographic ST-T abnormalities and risk of incident heart failure and its subtypes.Heart (British Cardiac Society) · 2026Article
- Transparent and Robust Artificial Intelligence-Driven Electrocardiogram Model for Left Ventricular Systolic Dysfunction.Diagnostics (Basel, Switzerland) · 2025Article
- Large Language Model-informed ECG Dual Attention Network for Heart Failure Risk Prediction.IEEE transactions on big data · 2025Article
- Unsupervised clustering of single-lead electrocardiograms associates with prevalent and incident heart failure in coronary artery disease.European heart journal. Digital health · 2025Article
- Electrocardiographic parameter profiles for differentiating hypertrophic cardiomyopathy stages.Journal of arrhythmia · 2025Article
- Cardiac Conduction Delay for Sodium Channel Antagonist Antiseizure Medications: An Analysis of the Canadian Longitudinal Study on Aging.Neurology · 2025Article
- Sex-Specific Changes in Cardiac Function and Electrophysiology During Progression of Adenine-Induced Chronic Kidney Disease in Mice.Journal of cardiovascular development and disease · 2024Article
- Detection of Right and Left Ventricular Dysfunction in Pediatric Patients Using Artificial Intelligence-Enabled ECGs.Journal of the American Heart Association · 2024Article
- Article
- Vectorcardiography Predicts Heart Failure in Patients Following ST Elevation Myocardial Infarction.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2024Article
- Prolonged ventricular repolarization associated with mild cognitive impairment and white matter hyperintensities: a cross-sectional study.Scientific reports · 2024Article
- Dynamic risk stratification of worsening heart failure using a deep learning-enabled implanted ambulatory single-lead electrocardiogram.European heart journal. Digital health · 2024Article
- Presence and utility of electrocardiographic abnormalities in long-term childhood cancer survivors.Heart (British Cardiac Society) · 2024Article
- Estimating Ejection Fraction from the 12 Lead ECG among Patients with Acute Heart Failure.medRxiv : the preprint server for health sciences · 2024Article
- Usefulness of electrocardiography QT interval for prediction of left ventricular diastolic dysfunction: a cross-sectional study.Annals of medicine and surgery (2012) · 2023Article
- An explainable artificial intelligence-enabled electrocardiogram analysis model for the classification of reduced left ventricular function.European heart journal. Digital health · 2023Article
- Ventricular Electrocardiographic Signatures Associated with Dementia and Plasma Alzheimer's Disease Biomarkers in Older Adults: A Population-Based Study.Journal of Alzheimer's disease : JAD · 2023Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundSeveral markers detected on the routine 12-lead ECG are associated with future heart failure events. We examined whether these markers are able to separate the risk of heart failure with reduced ejection fraction (HFrEF) from heart failure with preserved ejection fraction (HFpEF). METHODS AND
resultsWe analyzed data of 6664 participants (53% female; mean age 62±10 years) from MESA (Multi-Ethnic Study of Atherosclerosis) who were free of cardiovascular disease at baseline (2000-2002). A competing risks analysis was used to compare the association of several baseline ECG predictors with HFrEF and HFpEF detected during a median follow-up of 12.1 years. A total of 127 HFrEF and 117 HFpEF events were detected during follow-up. In a multivariable adjusted model, prolonged QRS duration, delayed intrinsicoid deflection, left-axis deviation, right-axis deviation, prolonged QT interval, abnormal QRS-T axis, left ventricular hypertrophy, ST/T-wave abnormalities, and left bundle-branch block were associated with HFrEF. In contrast, higher resting heart rate, abnormal P-wave axis, and abnormal QRS-T axis were associated with HFpEF. The risk of HFrEF versus HFpEF was significantly differently for delayed intrinsicoid deflection (hazard ratio: 4.90 [95% confidence interval (CI), 2.77-8.68] versus 0.94 [95% CI, 0.29-2.97]; comparison
conclusionsMarkers of ventricular repolarization and delayed ventricular activation are able to distinguish between the future risk of HFrEF and HFpEF. These findings suggest a role for ECG markers in the personalized risk assessment of heart failure subtypes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.