Evidence map›Paper›PMID 28546450›Full record

ArticleJournal of lipid research2017

Fatty acid binding protein 4/aP2-dependent BLT1R expression and signaling.

Ann V Hertzel, Hongliang Xu, Michael Downey, Nicholas Kvalheim, David A Bernlohr

Open access · hybridAbstract read
In one paragraph

Article in Journal of lipid research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Adipokines, adiposity, and atherosclerosis.Cellular and molecular life sciences : CMLS · 2022
    Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. FABP4 regulates eosinophil recruitment and activation in allergic airway inflammation.American journal of physiology. Lung cellular and molecular physiology · 2018
    Article
  16. [miR-203 inhibits lung cancer cell metastasis by targeting fatty acid binding protein 4].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ann V HertzelDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455.
Hongliang XuDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455.
Michael DowneyDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455.
Nicholas KvalheimDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455.
David A BernlohrDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455. Electronic address: bernl001@umn.edu.
University of Minnesota · US

Funding

Obesity and Energy Metabolism CoreP30DK050456 · NIDDK · UNIVERSITY OF MINNESOTA TWIN CITIES · PI CROW, SCOTT J · 1995 to 2015
$17.0M
LIPID BINDING PROTEINS IN OBESITY/DIABETES SYNDROMESR01DK053189 · NIDDK · UNIVERSITY OF MINNESOTA TWIN CITIES · PI BERNLOHR, DAVID A · 1998 to 2020
$5.6M
NIDDK NIH HHS P30 DK050456NIDDK NIH HHS R01 DK053189
6 · The paper itself

Abstract

Previous studies have shown that reduced levels of the adipocyte fatty acid binding protein (FABP)4 (AFABP/aP2), result in metabolic improvement including potentiated insulin sensitivity and attenuated atherosclerosis. Mechanistically, pharmacologic or genetic inhibition of FABP4 in macrophages upregulates UCP2, attenuates reactive oxygen species (ROS) production, polarizes cells toward the anti-inflammatory M2 state, and reduces leukotriene (LT) secretion. At the protein level, FABP4 stabilizes LTA

Indexed as

Signal TransductionAnimalsFatty Acid-Binding ProteinsGene Expression RegulationGene Knockout TechniquesLipopolysaccharidesMiceRAW 264.7 CellsReactive Oxygen SpeciesReceptors, Leukotriene B4RNA, MessengerUncoupling Protein 2Fabp4 protein, mouseFatty Acid-Binding ProteinsLipopolysaccharidesLtb4r2 protein, mouseReactive Oxygen SpeciesReceptors, Leukotriene B4RNA, MessengerUcp2 protein, mouseUncoupling Protein 2adipocyte myelin P2inflammationleukotriene B4 receptor 1leukotrieneslipid mediatorslipidsmacrophagessignal transduction

Identifiers

PMID28546450
PMCPMC5496033
OpenAlexW2619223263

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.