Evidence map›Paper›PMID 28546434›Full record

ArticleGenetics2017

Behavioral Deficits Following Withdrawal from Chronic Ethanol Are Influenced by SLO Channel Function in

Luisa L Scott, Scott J Davis, Rachel C Yen, Greg J Ordemann, Sarah K Nordquist, Deepthi Bannai, Jonathan T Pierce

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 32 citations in OpenAlex.

  1. TAXISCAN, Optimizing throughput and behavioral depth in standardbioRxiv : the preprint server for biology · 2026
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  2. AlteredeNeuro · 2026
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  5. AlteredbioRxiv : the preprint server for biology · 2025
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  11. Natural variation in protein kinase D modifies alcohol sensitivity inbioRxiv : the preprint server for biology · 2024
    Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Alcohol induces mitochondrial fragmentation and stress responses to maintain normal muscle function in Caenorhabditis elegans.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Article
  19. A Novel Peptide Restricts Ethanol Modulation of the BK Channel In Vitro and In Vivo.The Journal of pharmacology and experimental therapeutics · 2018
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Luisa L ScottWaggoner Center for Alcohol and Addiction Research, Cell and Molecular Biology, Center for Brain, Behavior, and Evolution, Department of Neuroscience, University of Texas at Austin, Texas 78712.
Scott J DavisWaggoner Center for Alcohol and Addiction Research, Cell and Molecular Biology, Center for Brain, Behavior, and Evolution, Department of Neuroscience, University of Texas at Austin, Texas 78712.
Rachel C YenWaggoner Center for Alcohol and Addiction Research, Cell and Molecular Biology, Center for Brain, Behavior, and Evolution, Department of Neuroscience, University of Texas at Austin, Texas 78712.
Greg J OrdemannWaggoner Center for Alcohol and Addiction Research, Cell and Molecular Biology, Center for Brain, Behavior, and Evolution, Department of Neuroscience, University of Texas at Austin, Texas 78712.
Sarah K NordquistWaggoner Center for Alcohol and Addiction Research, Cell and Molecular Biology, Center for Brain, Behavior, and Evolution, Department of Neuroscience, University of Texas at Austin, Texas 78712.
Deepthi BannaiWaggoner Center for Alcohol and Addiction Research, Cell and Molecular Biology, Center for Brain, Behavior, and Evolution, Department of Neuroscience, University of Texas at Austin, Texas 78712.
Jonathan T PierceWaggoner Center for Alcohol and Addiction Research, Cell and Molecular Biology, Center for Brain, Behavior, and Evolution, Department of Neuroscience, University of Texas at Austin, Texas 78712 jonps@austin.utexas.edu.
The University of Texas at Austin · US

Funding

A screen for peptides that alter BK channel-mediated alcohol intoxicationR01AA020992 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI ALDRICH, RICHARD, MIHIC, S JOHN · 2012 to 2016
$2.0M
Ethanol action through the BK potassium channelF32AA014313 · NIAAA · ERNEST GALLO CLINIC AND RESEARCH CENTER · PI PIERCE-SHIMOMURA, JONATHAN T · 2003 to 2005
$131k
Adaptive tissue permeability to alcohol in C. elegansR03AA020195 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI PIERCE, JONATHAN THOMAS · 2010 to 2011
$75k
The molecular basis for the action of ethanol on the BK channelF31AA021641 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI DAVIS, SCOTT J · 2012 to 2012
$38k
NIAAA NIH HHS F31 AA021641NIAAA NIH HHS F32 AA014313NIAAA NIH HHS R01 AA020992NIAAA NIH HHS R03 AA020195
6 · The paper itself

Abstract

Symptoms of withdrawal from chronic alcohol use are a driving force for relapse in alcohol dependence. Thus, uncovering molecular targets to lessen their severity is key to breaking the cycle of dependence. Using the nematode

Indexed as

AnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsEthanolLarge-Conductance Calcium-Activated Potassium ChannelsLocomotionMembrane Transport ProteinsNeuronsSubstance Withdrawal SyndromeCaenorhabditis elegans ProteinsEthanolLarge-Conductance Calcium-Activated Potassium ChannelsMembrane Transport Proteinsslo-1 protein, C elegansSLO-2 protein, C elegansalcoholbehaviorethanolpotassium channelslo-1withdrawal

Identifiers

PMID28546434
PMCPMC5500142
OpenAlexW2617077373

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.