ArticleThe Journal of biological chemistry2017
Disruption of mitochondrial electron transport chain function potentiates the pro-apoptotic effects of MAPK inhibition.
Open access · hybridAbstract readComparative Study
In one paragraph
Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
52 citing papers in PubMed, 85 citations in OpenAlex.
- Metabolic links between mitochondrial electron transport, glycolysis, and AMP-activated protein kinase signaling modulate hepatocellular carcinoma cell survival.Molecular and cellular biochemistry · 2026Article
- Bioinspired Artificial Bioenergetic Organelles: Design Principles, Nanofabrication and Therapeutic Translation.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- The Impact of Cadmium Telluride Quantum Dots on Male Reproductive Health: A Systematic Review of Toxicological Effects and Mechanisms.The world journal of men's health · 2026Review
- Impact of mitochondrial reductive stress due to respiratory chain limitation on cancer via posttranslational modifications.Redox biology · 2026Review
- Onconase Induces Apoptosis in Dabrafenib-Resistant Melanoma Cell Lines Through Dysregulation of ROS Homeostasis, Antioxidant Protein Expression, and Mitochondrial Dynamics.International journal of molecular sciences · 2026Article
- The Role of Mitochondrial ROS in Neoplastic Transformations, Progression and Therapeutic Targeting.Oncology research · 2026Review
- Interaction of lncRNA LENT with DHX36 regulates translation and suppresses autophagy in melanoma.Cell death & disease · 2025Article
- TRMU Confers Resistance of Melanoma Cells to Vemurafenib through Modulating Mitochondrial Activities.Journal of proteome research · 2025Article
- Mitochondrial bioenergetics and networks in melanoma: an update.Apoptosis : an international journal on programmed cell death · 2025Review
- Methods and Guidelines for Metabolism Studies: Applications to Cancer Research.International journal of molecular sciences · 2025Review
- Mitochondrial proteome landscape unveils key insights into melanoma severity and treatment strategies.Cancer · 2025Article
- The Key Role of COA6 in Pancreatic Ductal Adenocarcinoma: Metabolic Reprogramming and Regulation of the Immune Microenvironment.Journal of cellular and molecular medicine · 2025Article
- Cutaneous melanoma.Nature reviews. Disease primers · 2025Review
- The Role of HSP90 and TRAP1 Targets on Treatment in Hepatocellular Carcinoma.Molecular biotechnology · 2025Review
- Neuroprotective Effects of Asiatic Acid on Autophagy and Mitochondrial Integrity in a Parkinson's Disease Cellular Model.Journal of experimental pharmacology · 2025Article
- Role of Autophagy and AMPK in Cancer Stem Cells: Therapeutic Opportunities and Obstacles in Cancer.International journal of molecular sciences · 2024Review
- Fibroblast Growth Factor Receptor Inhibitors Decrease Proliferation of Melanoma Cell Lines and Their Activity Is Modulated by Vitamin D.International journal of molecular sciences · 2024Article
- Exploring the Complex and Multifaceted Interplay between Melanoma Cells and the Tumor Microenvironment.International journal of molecular sciences · 2023Review
- Vitamin D Modulates the Response of Patient-Derived Metastatic Melanoma Cells to Anticancer Drugs.International journal of molecular sciences · 2023Article
- SMN promotes mitochondrial metabolic maturation during myogenesis by regulating the MYOD-miRNA axis.Life science alliance · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Andrew P TrottaDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029.
Jesse D GellesDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029.
Madhavika N SerasingheDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029.
Patrick LoiDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029.
Jack L ArbiserAtlanta Veterans Administration Medical Center, Winship Cancer Institute, Atlanta, Georgia 30322; Emory University, School of Medicine, Department of Dermatology, Atlanta, Georgia 30322.
Jerry E ChipukDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029; Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York 10029; Diabetes, Obesity, and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029. Electronic address: jerry.chipuk@mssm.edu.
Icahn School of Medicine at Mount Sinai · USWinship Cancer Institute
Funding
THE TISCH CANCER INSTITUTE - CANCER CENTER SUPPORT GRANTP30CA196521 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Ramon E Parsons · 2015 to 2026
$35.4MTranslational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STREAMSON C CHUA · 2015 to 2026
$27.7MCutaneous Hemangiomas and Signal TransductionR01AR047901 · NIAMS · EMORY UNIVERSITY · PI ARBISER, JACK L · 2001 to 2018
$4.3M(PQ5) Role of Mitochondrial Division in Cancer BiologyR01CA206005 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CHIPUK, JERRY EDWARD · 2016 to 2020
$1.7MFunction and regulation of the BCL-2 familyR01CA157740 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CHIPUK, JERRY EDWARD · 2011 to 2015
$1.7MEthanol-mediated inhibition of the S1P lyase results in disruption of apoptotic machinery and lymphocyte egress from lymphoid tissueF31AA024681 · NIAAA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GELLES-HURWITZ, JESSE · 2015 to 2018
$155kNCI NIH HHS P30 CA196521NCI NIH HHS R01 CA157740NCI NIH HHS R01 CA206005NIAAA NIH HHS F31 AA024681NIAMS NIH HHS R01 AR047901NIDDK NIH HHS P30 DK020541
Abstract
The mitochondrial network is a major site of ATP production through the coupled integration of the electron transport chain (ETC) with oxidative phosphorylation. In melanoma arising from the V600E mutation in the kinase v-RAF murine sarcoma viral oncogene homolog B (BRAF
Indexed as
Adenosine TriphosphateAllyl CompoundsAntineoplastic Agents, PhytogenicApoptosisBiphenyl CompoundsCDC2 Protein KinaseCell Line, TumorCyclin-Dependent Kinase 2Cyclin-Dependent KinasesElectron Transport Chain Complex ProteinsElectron Transport Complex IElectron Transport Complex IIG1 PhaseHumansLignansMAP Kinase Signaling SystemAdenosine TriphosphateAllyl CompoundsAntineoplastic Agents, PhytogenicBiphenyl CompoundsCDC2 Protein KinaseCDK1 protein, humanCDK2 protein, humanCyclin-Dependent Kinase 2Cyclin-Dependent KinasesElectron Transport Chain Complex ProteinsElectron Transport Complex IElectron Transport Complex IIhonokiolLignansNeoplasm ProteinsPhenolsProtein Kinase InhibitorsReactive Oxygen SpeciesUncoupling Agentsapoptosismitochondriamitochondrial dynamicsmitochondrial respiratory chain complexoncogenerespirationtargeted therapy
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.