Evidence map›Paper›PMID 28546324›Full record

ArticleStroke2017

Risk Factors for Pregnancy-Associated Stroke in Women With Preeclampsia.

Eliza C Miller, Hajere J Gatollari, Gloria Too, Amelia K Boehme, Lisa Leffert, Randolph S Marshall, Mitchell S V Elkind, Joshua Z Willey

Open access · bronzeAbstract read
In one paragraph

Article in Stroke, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
9.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 116 citations in OpenAlex.

  1. Article
  2. Observational
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Risk factors of intracranial haemorrhage in preeclampsia: a case-control study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Article
  10. Article
  11. The Impact of Sex and Gender on Stroke.Circulation research · 2022
    Review
  12. Article
  13. Role of MicroRNAs in Cardiac Disease with Stroke in Pregnancy.Oxidative medicine and cellular longevity · 2022
    Review
  14. Review
  15. Review
  16. Article
  17. Stroke in Pregnancy: A Multidisciplinary Approach.Obstetrics and gynecology clinics of North America · 2021
    Review
  18. Review
  19. The Prevalence of Ectopic Gestation: A Five-Year Study of 1273 Cases.International journal of general medicine · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Eliza C MillerFrom the Department of Neurology, College of Physicians and Surgeons (E.C.M., A.K.B., R.S.M., M.S.V.E., J.Z.W.), Department of Epidemiology, Mailman School of Public Health (H.J.G., A.K.B., M.S.V.E.), and Department of Obstetrics and Gynecology (G.T.), Columbia University, New York, NY; and Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston (L.L.). ecm2137@cumc.columbia.edu.
Hajere J GatollariFrom the Department of Neurology, College of Physicians and Surgeons (E.C.M., A.K.B., R.S.M., M.S.V.E., J.Z.W.), Department of Epidemiology, Mailman School of Public Health (H.J.G., A.K.B., M.S.V.E.), and Department of Obstetrics and Gynecology (G.T.), Columbia University, New York, NY; and Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston (L.L.).
Gloria TooFrom the Department of Neurology, College of Physicians and Surgeons (E.C.M., A.K.B., R.S.M., M.S.V.E., J.Z.W.), Department of Epidemiology, Mailman School of Public Health (H.J.G., A.K.B., M.S.V.E.), and Department of Obstetrics and Gynecology (G.T.), Columbia University, New York, NY; and Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston (L.L.).
Amelia K BoehmeFrom the Department of Neurology, College of Physicians and Surgeons (E.C.M., A.K.B., R.S.M., M.S.V.E., J.Z.W.), Department of Epidemiology, Mailman School of Public Health (H.J.G., A.K.B., M.S.V.E.), and Department of Obstetrics and Gynecology (G.T.), Columbia University, New York, NY; and Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston (L.L.).
Lisa LeffertFrom the Department of Neurology, College of Physicians and Surgeons (E.C.M., A.K.B., R.S.M., M.S.V.E., J.Z.W.), Department of Epidemiology, Mailman School of Public Health (H.J.G., A.K.B., M.S.V.E.), and Department of Obstetrics and Gynecology (G.T.), Columbia University, New York, NY; and Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston (L.L.).
Randolph S MarshallFrom the Department of Neurology, College of Physicians and Surgeons (E.C.M., A.K.B., R.S.M., M.S.V.E., J.Z.W.), Department of Epidemiology, Mailman School of Public Health (H.J.G., A.K.B., M.S.V.E.), and Department of Obstetrics and Gynecology (G.T.), Columbia University, New York, NY; and Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston (L.L.).
Mitchell S V ElkindFrom the Department of Neurology, College of Physicians and Surgeons (E.C.M., A.K.B., R.S.M., M.S.V.E., J.Z.W.), Department of Epidemiology, Mailman School of Public Health (H.J.G., A.K.B., M.S.V.E.), and Department of Obstetrics and Gynecology (G.T.), Columbia University, New York, NY; and Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston (L.L.).
Joshua Z WilleyFrom the Department of Neurology, College of Physicians and Surgeons (E.C.M., A.K.B., R.S.M., M.S.V.E., J.Z.W.), Department of Epidemiology, Mailman School of Public Health (H.J.G., A.K.B., M.S.V.E.), and Department of Obstetrics and Gynecology (G.T.), Columbia University, New York, NY; and Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston (L.L.).
Massachusetts General Hospital · US

Funding

Stroke Trials Network of Columbia and CornellU24NS107237 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI EDWARD SANDER CONNOLLY, Randolph S Marshall · 2018 to 2026
$3.1M
New York Stroke Trials Network of Columbia and Cornell (NYCCSTN)U10NS086728 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARSHALL, RANDOLPH S · 2013 to 2017
$2.0M
NINDS NIH HHS U10 NS086728NINDS NIH HHS U24 NS107237
6 · The paper itself

Abstract

background and purposePreeclampsia affects 3% to 8% of pregnancies and increases risk of pregnancy-associated stroke (PAS). Data are limited on which women with preeclampsia are at highest risk for PAS.

methodsUsing billing data from the 2003 to 2012 New York State Department of Health inpatient database, we matched women with preeclampsia and PAS 1:3 to preeclamptic controls based on age and race/ethnicity. Pre-defined PAS risk factors included pregnancy complications, infection present on admission, vascular risk factors, prothrombotic states, and coagulopathies. We constructed multivariable conditional logistic regression models to calculate the odds ratios (ORs) and 95% confidence intervals (95% CIs) for independent risk factors for PAS.

resultsAmong women aged 12 to 55 years admitted to New York State hospitals for any reason during the study period (n=3 373 114), 88 857 had preeclampsia, and 197 of whom (0.2%) had PAS. In multivariable analysis, women with preeclampsia and stroke were more likely than controls to have severe preeclampsia or eclampsia (OR, 7.2; 95% confidence interval [CI], 4.6-11.3), infections present on admission (OR, 3.0; 95% CI, 1.6-5.8), prothrombotic states (OR, 3.5; 95% CI, 1.3-9.2), coagulopathies (OR, 3.1; 95% CI, 1.3-7.1), or chronic hypertension (OR, 3.2; 95% CI, 1.8-5.5). Additional analyses matched and stratified by severity of preeclampsia confirmed these results.

conclusionsInfections, chronic hypertension, coagulopathies, and underlying prothrombotic conditions increase PAS risk in women with preeclampsia. These women may warrant closer monitoring.

Indexed as

AdolescentAdultCase-Control StudiesCommunicable DiseasesFemaleHumansHypertensionNew YorkPatient AdmissionPre-EclampsiaPregnancyRisk FactorsStrokeYoung Adultcerebrovascular diseasespreeclampsiapregnancyrisk factorsstrokewomen

Identifiers

PMID28546324
PMCPMC5539968
OpenAlexW2618511764

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.