ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017
Evidence for Functional Networks within the Human Brain's White Matter.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 138 papers.
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Who cites it
138 citing papers in PubMed, 249 citations in OpenAlex.
- Fornix Mediates Information Propagation in Brain Networks Following DLPFC-Targeted rTMS in Alzheimer's Disease: A Randomized Controlled Trial.CNS neuroscience & therapeutics · 2025Trial
- Elucidation of the relationship between sensory processing and white matter using diffusion tensor imaging tractography in young adults.Scientific reports · 2021Trial
- Widespread higher fractional anisotropy associates to better cognitive functions in individuals at ultra-high risk for psychosis.Human brain mapping · 2019Trial
- Frequency-dependent, asymmetric, and dynamic alterations of white matter function in primary hemifacial spasm: a multiband resting-state fMRI study.Brain structure & function · 2026Article
- White Matter Slow-4 fALFF as a Complementary Marker in the Multimodal Alzheimer's Disease Biomarker Landscape.bioRxiv : the preprint server for biology · 2026Article
- A Distinct Second Spectral Peak in White Matter BOLD Signals: Mathematical Modeling, Spatial Distribution and Age-Related Evolution.Research square · 2026Article
- Impaired white matter functional networks topology changed with white matter hyperintensities burden and relationship to cognition.Brain imaging and behavior · 2026Article
- A high-resolution functional network-organized atlas of human superficial white matter from ultra-high-field diffusion MRI.iScience · 2026Article
- Electrophysiological features of signals recorded from white matter.bioRxiv : the preprint server for biology · 2026Article
- White-Matter BOLD Encoding Beyond Marginal Connectivity.bioRxiv : the preprint server for biology · 2026Article
- Disrupted white matter functional connectivity in post-stroke cognitive impairment: Insights from resting-state fMRI.Brain imaging and behavior · 2026Article
- Mapping the functional connectome between grey matter and white matter.Communications biology · 2026Article
- Mouse white matter matters: cortical origins and spatial organization of mouse white matter tracts.Brain structure & function · 2026Article
- Investigating White Matter Functional Network Connectivity Across the Alzheimer's Disease Spectrum Using Resting-State fMRI.bioRxiv : the preprint server for biology · 2026Article
- Altered Topological Properties of White-Matter Functional Networks in Young Smokers.Addiction biology · 2026Article
- Dynamic Analysis of Gray Matter and White Matter Functional Network Connectivity in Individuals with Temporal Lobe Epilepsy.Research square · 2026Article
- Investigating white matter functional network connectivity across the Alzheimer's disease spectrum using resting-state fMRI.Frontiers in neuroimaging · 2026Article
- Diffusion tensor imaging-functional MRI fusion reveals disrupted white matter structure-function coupling in HIV-associated asymptomatic neurocognitive impairment.Frontiers in neuroscience · 2026Article
- GWM-HFN, a Gray-White Matter heterogeneous fusion network for functional connectomes.Communications biology · 2025Article
- White matter structure-function coupling alteration is associated with plasma biomarkers and cognition in Alzheimer's disease.European radiology · 2025Article
78 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Investigation of the functional macro-scale organization of the human cortex is fundamental in modern neuroscience. Although numerous studies have identified networks of interacting functional modules in the gray-matter, limited research was directed to the functional organization of the white-matter. Recent studies have demonstrated that the white-matter exhibits blood oxygen level-dependent signal fluctuations similar to those of the gray-matter. Here we used these signal fluctuations to investigate whether the white-matter is organized as functional networks by applying a clustering analysis on resting-state functional MRI (RSfMRI) data from white-matter voxels, in 176 subjects (of both sexes). This analysis indicated the existence of 12 symmetrical white-matter functional networks, corresponding to combinations of white-matter tracts identified by diffusion tensor imaging. Six of the networks included interhemispheric commissural bridges traversing the corpus callosum. Signals in white-matter networks correlated with signals from functional gray-matter networks, providing missing knowledge on how these distributed networks communicate across large distances. These findings were replicated in an independent subject group and were corroborated by seed-based analysis in small groups and individual subjects. The identified white-matter functional atlases and analysis codes are available at http://mind.huji.ac.il/white-matter.aspx Our results demonstrate that the white-matter manifests an intrinsic functional organization as interacting networks of functional modules, similarly to the gray-matter, which can be investigated using RSfMRI. The discovery of functional networks within the white-matter may open new avenues of research in cognitive neuroscience and clinical neuropsychiatry.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.