SynthesisPsychological medicine2018
Prefrontal cortical thinning links to negative symptoms in schizophrenia via the ENIGMA consortium.
Abstract readMeta-AnalysisMulticenter Study
In one paragraph
Synthesis in Psychological medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 8 of them syntheses that pooled it.
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83citing papers in PubMed, 8 pooled it
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Who cites it
83 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- Estimating Multimodal Structural Brain Variability in Schizophrenia Spectrum Disorders: A Worldwide ENIGMA Study.The American journal of psychiatry · 2025Pooled it
- Neuropsychological Performance Among Individuals at Clinical High-Risk for Psychosis vs Putatively Low-Risk Peers With Other Psychopathology: A Systematic Review and Meta-Analysis.Schizophrenia bulletin · 2022Pooled it
- Cross disorder comparisons of brain structure in schizophrenia, bipolar disorder, major depressive disorder, and 22q11.2 deletion syndrome: A review of ENIGMA findings.Psychiatry and clinical neurosciences · 2022Pooled it
- Cortical and subcortical neuroanatomical signatures of schizotypy in 3004 individuals assessed in a worldwide ENIGMA study.Molecular psychiatry · 2022Pooled it
- ENIGMA + COINSTAC: Improving Findability, Accessibility, Interoperability, and Re-usability.Neuroinformatics · 2022Pooled it
- ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries.Translational psychiatry · 2020Pooled it
- Motor cortical plasticity in schizophrenia: A meta-analysis of Transcranial Magnetic Stimulation - Electromyography studies.Schizophrenia research · 2019Pooled it
- Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium.Biological psychiatry · 2018Pooled it
- Functional gradient reorganization and transcriptomic signatures underlying 1 Hz rTMS treatment in first-episode schizophrenia following right orbitofrontal cortex stimulation.NeuroImage. Clinical · 2026Trial
- Cortical Structures Underlying Schizophrenia and Sex Differences in Preadolescents: An Adolescent Brain Cognitive Development Study.Child psychiatry and human development · 2026Article
- Shared Genetic Networks in Schizophrenia and Bipolar Disorder: Hippocampal Volume-Mediated Neurobiological Mechanisms.Schizophrenia bulletin · 2026Article
- Inhibitory control deficits and ventral attention network alterations linked to apathy in schizophrenia.Translational psychiatry · 2026Article
- Individualized cortical gradient and network topology reveal symptom-linked disruptions and neurobiological subtypes in schizophrenia.medRxiv : the preprint server for health sciences · 2026Article
- Orbitofrontal Thickness and Network Associations as Transdiagnostic Signature of Amotivation Along the Bipolar-Schizophrenia Spectrum.Schizophrenia bulletin · 2026Article
- An ENIGMA Consortium study of the relationship between white matter microstructure and positive and negative symptom severity in patients with schizophrenia.Schizophrenia (Heidelberg, Germany) · 2026Article
- Vertexwise Cortical Deviation Mapping (VCDM): A precision approach to cortical thickness assessment in non-affective psychosis.Brain imaging and behavior · 2026Article
- Frontotemporal cortical thinning and insular surface area reduction in schizophrenia with predominant negative symptoms.BMC psychiatry · 2026Article
- Medication and atypical brain maturation in psychosis associated with long-term cognitive decline and symptom progression.The British journal of psychiatry : the journal of mental science · 2025Article
- A novel strategy for enhanced schizophrenia detection using established CNN architectures.BMC medical imaging · 2025Article
- Subtyping schizophrenia via machine learning by using structural neuroimaging.Translational psychiatry · 2025Review
23 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
59 authors.
E WaltonDepartment of Psychology,Georgia State University,Atlanta, GA 30302,USA.
D P HibarImaging Genetics Center,Mark and Mary Stevens Institute for Neuroimaging & Informatics,University of Southern California,Marina del Rey, CA,USA.
T G M van ErpDepartment of Psychiatry and Human Behavior,University of California,Irvine,California.
S G PotkinDepartment of Psychiatry and Human Behavior,University of California,Irvine,California.
R Roiz-SantiañezDepartment of Psychiatry,University Hospital Marqués de Valdecilla,School of Medicine,University of Cantabria-IDIVAL,Avda. Valdecilla s/n, 39008,Santander,Spain.
B Crespo-FacorroDepartment of Psychiatry,University Hospital Marqués de Valdecilla,School of Medicine,University of Cantabria-IDIVAL,Avda. Valdecilla s/n, 39008,Santander,Spain.
P Suarez-PinillaDepartment of Psychiatry,University Hospital Marqués de Valdecilla,School of Medicine,University of Cantabria-IDIVAL,Avda. Valdecilla s/n, 39008,Santander,Spain.
N E M van HarenDepartment of Psychiatry,Brain Center Rudolf Magnus,University Medical Center Utrecht,Utrecht,The Netherlands.
S M C de ZwarteDepartment of Psychiatry,Brain Center Rudolf Magnus,University Medical Center Utrecht,Utrecht,The Netherlands.
R S KahnDepartment of Psychiatry,Brain Center Rudolf Magnus,University Medical Center Utrecht,Utrecht,The Netherlands.
W CahnDepartment of Psychiatry,Brain Center Rudolf Magnus,University Medical Center Utrecht,Utrecht,The Netherlands.
N T DoanNORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction,University of Oslo,P.O. Box 4956 Nydalen, 0424 Oslo,Norway.
K N JørgensenNORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction,University of Oslo,P.O. Box 4956 Nydalen, 0424 Oslo,Norway.
T P GurholtNORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction,University of Oslo,P.O. Box 4956 Nydalen, 0424 Oslo,Norway.
I AgartzNORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction,University of Oslo,P.O. Box 4956 Nydalen, 0424 Oslo,Norway.
O A AndreassenNORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction,University of Oslo,P.O. Box 4956 Nydalen, 0424 Oslo,Norway.
L T WestlyeNORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction,Oslo University Hospital,P.O. Box 4956 Nydalen, 0424, Oslo,Norway.
I MelleNORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction,University of Oslo,P.O. Box 4956 Nydalen, 0424 Oslo,Norway.
A O BergNORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction,University of Oslo,P.O. Box 4956 Nydalen, 0424 Oslo,Norway.
L Morch-JohnsenNORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction,University of Oslo,P.O. Box 4956 Nydalen, 0424 Oslo,Norway.
A FærdenDivision of Mental Health and Addiction,Oslo University Hospital,P.O. Box 4956 Nydalen, 0424, Oslo,Norway.
L FlycktDepartment of Clinical Neuroscience,Karolinska Institutet, Centre for Psychiatry Research,Norra Stationsgatan 69, 113 64 Stockholm,Sweden.
H Fatouros-BergmanDepartment of Clinical Neuroscience,Karolinska Institutet, Centre for Psychiatry Research,Norra Stationsgatan 69, 113 64 Stockholm,Sweden.
Karolinska Schizophrenia Project Consortium (KaSP)
E G JönssonNORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction,University of Oslo,P.O. Box 4956 Nydalen, 0424 Oslo,Norway.
R HashimotoMolecular Research Center for Children's Mental Development,United Graduate School of Child Development,Osaka University,D3, 2-2, Yamadaoka, Suita, Osaka, 565-0871,Japan.
H YamamoriDepartment of Psychiatry,Osaka University Graduate School of Medicine D3,2-2, Yamadaoka, Suita, Osaka, 565-0871,Japan.
M FukunagaDivision of Cerebral Integration,National Institute for Physiological Sciences,38 Nishigonaka Myodaiji,Okazaki, Aichi, 444-8585,Japan.
N JahanshadImaging Genetics Center,Mark and Mary Stevens Institute for Neuroimaging & Informatics,University of Southern California,Marina del Rey, CA,USA.
P De RossiNESMOS Department (Neurosciences, Mental Health and Sensory Functions),School of Medicine and Psychology, Sapienza University,Rome,Italy.
F PirasDepartment of Clinical and Behavioural Neurology,IRCCS Santa Lucia Foundation,00179, Rome,Italy.
N BanajDepartment of Clinical and Behavioural Neurology,IRCCS Santa Lucia Foundation,00179, Rome,Italy.
G SpallettaDepartment of Clinical and Behavioural Neurology,IRCCS Santa Lucia Foundation,00179, Rome,Italy.
R E GurBrain Behavior Laboratory,University of Pennsylvania,Philadelphia, PA 19104,USA.
R C GurBrain Behavior Laboratory,University of Pennsylvania,Philadelphia, PA 19104,USA.
D H WolfBrain Behavior Laboratory,University of Pennsylvania,Philadelphia, PA 19104,USA.
T D SatterthwaiteBrain Behavior Laboratory,University of Pennsylvania,Philadelphia, PA 19104,USA.
L M BeardBrain Behavior Laboratory,University of Pennsylvania,Philadelphia, PA 19104,USA.
I E SommerDepartment of Psychiatry,Brain Center Rudolf Magnus,University Medical Center Utrecht,Utrecht,The Netherlands.
S KoopsDepartment of Psychiatry,Brain Center Rudolf Magnus,University Medical Center Utrecht,Utrecht,The Netherlands.
O GruberDepartment of Psychiatry and Psychotherapy,Center for Translational Research in Systems Neuroscience and Psychiatry,University Medical Center Göttingen,Von-Siebold-Str. 5, 37075 Göttingen,Germany.
A RichterDepartment of Psychiatry and Psychotherapy,Center for Translational Research in Systems Neuroscience and Psychiatry,University Medical Center Göttingen,Von-Siebold-Str. 5, 37075 Göttingen,Germany.
B KrämerDepartment of Psychiatry and Psychotherapy,Center for Translational Research in Systems Neuroscience and Psychiatry,University Medical Center Göttingen,Von-Siebold-Str. 5, 37075 Göttingen,Germany.
S KellyImaging Genetics Center,Mark and Mary Stevens Institute for Neuroimaging & Informatics,University of Southern California,Marina del Rey, CA,USA.
G DonohoeCentre for Neuroimaging and Cognitive Genomics (NICOG), NCBES Galway Neuroscience Centre, National University of Ireland Galway,Galway,Ireland.
C McDonaldCentre for Neuroimaging and Cognitive Genomics (NICOG), NCBES Galway Neuroscience Centre, National University of Ireland Galway,Galway,Ireland.
D M CannonCentre for Neuroimaging and Cognitive Genomics (NICOG), NCBES Galway Neuroscience Centre, National University of Ireland Galway,Galway,Ireland.
A CorvinTrinity College,Dublin,Ireland.
M GillTrinity College,Dublin,Ireland.
A Di GiorgioSection of Psychiatry and Psychology, IRCCS Casa Sollievo della Sofferenza,S.G. Rotondo (FG), 71013,Italy.
A BertolinoPsychiatric Neuroscience Group,University of Bari 'Aldo Moro',Bari, 70124,Italy.
S LawrieDivision of Psychiatry,University of Edinburgh,Royal Edinburgh Hospital,Morningside, Edinburgh, EH10 5HF,UK.
T NicksonDivision of Psychiatry,University of Edinburgh,Royal Edinburgh Hospital,Morningside, Edinburgh, EH10 5HF,UK.
H C WhalleyDivision of Psychiatry,University of Edinburgh,Royal Edinburgh Hospital,Morningside, Edinburgh, EH10 5HF,UK.
E NeilsonDivision of Psychiatry,University of Edinburgh,Royal Edinburgh Hospital,Morningside, Edinburgh, EH10 5HF,UK.
V D CalhounThe Mind Research Network,Albuquerque, NM 87106,USA.
P M ThompsonImaging Genetics Center,Mark and Mary Stevens Institute for Neuroimaging & Informatics,University of Southern California,Marina del Rey, CA,USA.
J A TurnerDepartment of Psychology and Neuroscience Institute,Georgia State University,Atlanta, GA 30302,USA.
S EhrlichDivision of Psychological and Social Medicine and Developmental Neurosciences,Faculty of Medicine,Technische Universität Dresden,Fetscherstr. 74, 01307 Dresden,Germany.
Funding
Transcranial Direct Current Stimulation for Treatment of Auditory Verbal HalluciP20GM103472 · NIGMS · THE MIND RESEARCH NETWORK · PI SUI, JING · 2012 to 2017
$14.3MTraining U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1MMultivariate methods for identifying multitask/multimodal brain imaging biomarkersR01EB006841 · NIBIB · THE MIND RESEARCH NETWORK · PI VINCE D CALHOUN, Sergey Plis · 2007 to 2026
$9.8MMining the Genomewide Scan: Genetic Profiles of Structural Loss in Schizophrenia: AD/ADRD supplementR01MH094524 · NIMH · THE MIND RESEARCH NETWORK · PI CALHOUN, VINCE D, TURNER, JESS · 2012 to 2021
$6.3MInformed Data-Driven Fusion of Behavior, Brain Function, and GenesR01EB005846 · NIBIB · THE MIND RESEARCH NETWORK · PI CALHOUN, VINCE D · 2005 to 2016
$5.5MUnified multivariate data-driven solutions for static and dynamic brain connectivityR01EB020407 · NIBIB · THE MIND RESEARCH NETWORK · PI ADALI, TULAY, CALHOUN, VINCE D · 2015 to 2018
$2.7MQuantitative Behavioral and Imaging Phenotypes of Amotivation in SchizophreniaR01MH101111 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI WOLF, DANIEL H · 2013 to 2016
$1.6MFunctional neuroimaging of reward and motivation deficits in schizophreniaK23MH085096 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI WOLF, DANIEL H · 2009 to 2013
$897kNIBIB NIH HHS R01 EB005846NIBIB NIH HHS R01 EB006841NIBIB NIH HHS R01 EB020407NIBIB NIH HHS U54 EB020403NIGMS NIH HHS P20 GM103472NIMH NIH HHS K23 MH085096NIMH NIH HHS R01 MH094524NIMH NIH HHS R01 MH101111
Abstract
backgroundOur understanding of the complex relationship between schizophrenia symptomatology and etiological factors can be improved by studying brain-based correlates of schizophrenia. Research showed that impairments in value processing and executive functioning, which have been associated with prefrontal brain areas [particularly the medial orbitofrontal cortex (MOFC)], are linked to negative symptoms. Here we tested the hypothesis that MOFC thickness is associated with negative symptom severity.
methodsThis study included 1985 individuals with schizophrenia from 17 research groups around the world contributing to the ENIGMA Schizophrenia Working Group. Cortical thickness values were obtained from T1-weighted structural brain scans using FreeSurfer. A meta-analysis across sites was conducted over effect sizes from a model predicting cortical thickness by negative symptom score (harmonized Scale for the Assessment of Negative Symptoms or Positive and Negative Syndrome Scale scores).
resultsMeta-analytical results showed that left, but not right, MOFC thickness was significantly associated with negative symptom severity (β std = -0.075; p = 0.019) after accounting for age, gender, and site. This effect remained significant (p = 0.036) in a model including overall illness severity. Covarying for duration of illness, age of onset, antipsychotic medication or handedness weakened the association of negative symptoms with left MOFC thickness. As part of a secondary analysis including 10 other prefrontal regions further associations in the left lateral orbitofrontal gyrus and pars opercularis emerged.
conclusionsUsing an unusually large cohort and a meta-analytical approach, our findings point towards a link between prefrontal thinning and negative symptom severity in schizophrenia. This finding provides further insight into the relationship between structural brain abnormalities and negative symptoms in schizophrenia.
Indexed as
AdultFemaleFunctional LateralityHumansImage Processing, Computer-AssistedInternationalityLinear ModelsMagnetic Resonance ImagingMalePrefrontal CortexPsychiatric Status Rating ScalesSchizophreniaSchizophrenic PsychologyCortical thicknessENIGMAFreeSurfermedial orbitofrontal cortexMRInegative symptomsPANSSSANSschizophrenia
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