Evidence map›Paper›PMID 28545575›Full record

ArticleBMC cardiovascular disorders2017

Impaired chronotropic response to physical activities in heart failure patients.

Hong Shen, Jianrong Zhao, Xiaohong Zhou, Jingbo Li, Qing Wan, Jing Huang, Hui Li, Liqun Wu, Shungang Yang, Ping Wang

Registry-linked trialOpen access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cardiovascular disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02358603 (Investigation of the Chronotropic Incompetence Diagnostic Algorithm in Heart Failure Patients), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02358603 naterminatednot on this map

Investigation of the Chronotropic Incompetence Diagnostic Algorithm in Heart Failure Patients

TypeinterventionalSponsorMedtronic Cardiac Rhythm and Heart FailureRan2014 to 2015Enrolled48ConditionsHeart FailureArmsChronotropic Incompetence Diagnostic Algorithm
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Hong ShenDepartment of Cardiology, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.
Jianrong ZhaoDepartment of Cardiology, Ruijin Hospital Luwan Branch, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xiaohong ZhouCardiac Rhythm and Heart Failure, Research and Technology, Medtronic plc, Mounds View, MN, USA.
Jingbo LiDepartment of Cardiology, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, China. jbli@medmail.com.cn.ORCID 0000-0001-6121-6532
Qing WanDepartment of Cardiology, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.
Jing HuangDepartment of Cardiology, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.
Hui LiDepartment of Cardiology, Ruijin Hospital Luwan Branch, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Liqun WuDepartment of Cardiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shungang YangCardiac Rhythm and Heart Failure, Research and Technology, Medtronic plc, Mounds View, MN, USA.
Ping WangCardiac Rhythm and Heart Failure, Research and Technology, Medtronic plc, Mounds View, MN, USA.
Shanghai Jiao Tong University · CNMedtronic (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWhile exercise-based cardiac rehabilitation has a beneficial effect on heart failure hospitalization and mortality, it is limited by the presence of chronotropic incompetence (CI) in some patients. This study explored the feasibility of using wearable devices to assess impaired chronotropic response in heart failure patients.

methodsForty patients with heart failure (left ventricular ejection fraction, LVEF: 44.6 ± 5.8; age: 54.4 ± 11.7) received ECG Holter and accelerometer to monitor heart rate (HR) and physical activities during symptom-limited treadmill exercise testing, 6-min hall walk (6MHW), and 24-h daily living. CI was defined as maximal HR during peak exercise testing failing to reach 70% of age-predicted maximal HR (APMHR, 220 - age). The correlation between HR and physical activities in Holter-accelerometer recording was analyzed.

resultsOf 40 enrolled patients, 26 were able to perform treadmill exercise testing. Based on exercise test reports, 13 (50%) of 26 patients did not achieve at least 70% of APMHR (CI patients). CI patients achieved a lower % APMHR (62.0 ± 6.3%) than non-CI patients who achieved 72.0 ± 1.2% of APMHR (P < 0.0001). When Holter-accelerometer recording was used to assess chronotropic response, the percent APMHR achieved during 6MHW and physical activities was significantly lower in CI patients than in non-CI patients. CI patients had a significantly shorter 6MHW distance and less physical activity intensity than non-CI patients.

conclusionThe study found impaired chronotropic response in 50% of heart failure patients who took treadmill exercise testing. The wearable Holter-accelerometer recording could help to identify impaired chronotropic response to physical activities in heart failure patients.

trial registrationClinicalTrials.gov ID NCT02358603 . Registered 16 May 2014.

Indexed as

ActigraphyElectrocardiography, AmbulatoryHeart RateAdaptation, PhysiologicalAdultAgedCardiac RehabilitationChinaExercise TherapyFeasibility StudiesFemaleFitness TrackersHeart FailureHumansMaleMiddle Aged6 min hall walkChronotropic incompetenceHeart failure rehabilitationHeart rateTreadmill exercise testing

Identifiers

PMID28545575
PMCPMC5445286
OpenAlexW2620146329

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.