ArticleBMC complementary and alternative medicine2017
Cytotoxicity of the methanol extracts of Elephantopus mollis, Kalanchoe crenata and 4 other Cameroonian medicinal plants towards human carcinoma cells.
Article in BMC complementary and alternative medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 56 citations in OpenAlex.
- Ethyl acetate extract ofResearch in pharmaceutical sciences · 2026Article
- Natural Products in Gambeya lacourtiana (Sapotaceae): Identification, In Vitro Cytoxicity, and Deep Learning-Based Pharmacokinetic Prediction.Chemistry & biodiversity · 2026Article
- Synthesis, characterization, antioxidant and anticancer potential of Kalanchoe pinnata green synthesized silver nanoparticles targeting p53/MDM2 nexus in hepatic cancer: integrated in vitro and in silico study.Scientific reports · 2026Article
- Petroleum ether extract of3 Biotech · 2025Article
- Kalanchoe pinnata (Lam.) Pers. Leaf ethanolic extract exerts selective anticancer activity through ROS-induced apoptotic cell death in human cancer cell lines.BMC complementary medicine and therapies · 2024Article
- A Review of the Popular Uses, Anatomical, Chemical, and Biological Aspects of Kalanchoe (Crassulaceae): A Genus of Plants Known as "Miracle Leaf".Molecules (Basel, Switzerland) · 2023Review
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- Biological Activities and Chemical Profiles ofPlants (Basel, Switzerland) · 2023Article
- Potential ofMolecules (Basel, Switzerland) · 2022Review
- Phytochemical Characterization, Anti-Oxidant, Anti-Enzymatic and Cytotoxic Effects ofMolecules (Basel, Switzerland) · 2022Article
- A Review on Traditionally Used African Medicinal PlantPlants (Basel, Switzerland) · 2022Review
- Ethyl acetate extract of Elephantopus mollis Kunth induces apoptosis in human gastric cancer cells.BMC complementary medicine and therapies · 2021Article
- LC-ToF-ESI-MS Patterns of Hirsutinolide-like Sesquiterpenoids Present in theMolecules (Basel, Switzerland) · 2021Article
- Ethiopian Medicinal Plants Traditionally Used for the Treatment of Cancer; Part 3: Selective Cytotoxic Activity of 22 Plants against Human Cancer Cell Lines.Molecules (Basel, Switzerland) · 2021Article
- Myricetin: versatile plant based flavonoid for cancer treatment by inducing cell cycle arrest and ROS-reliant mitochondria-facilitated apoptosis in A549 lung cancer cells and in silico prediction.Molecular and cellular biochemistry · 2021Article
- Phytochemical profile, antioxidant and cytotoxic potential ofSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2020Article
- LC-MS Analysis, 15-Lipoxygenase Inhibition, Cytotoxicity, and Genotoxicity ofJournal of tropical medicine · 2020Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCancer still constitutes one of the major health concerns globally, causing serious threats on patients, their families, and the healthcare system.
methodsIn this study, the cytotoxicity of the methanol extract of Elephantopus mollis whole plant (EMW), Enantia chlorantha bark (ECB), Kalanchoe crenata leaves (KCL), Lophira alata bark (LAB), Millettia macrophylla leaves (MML) and Phragmanthera capitata leaves (PCL) towards five human solid cancer cell lines and normal CRL2120 fibroblasts, was evaluated. Extracts were subjected to qualitative chemical screening of their secondary metabolite contents using standard methods. The cytotoxicity of samples was evaluated using neutral red uptake (NR) assay meanwhile caspase activation was detected by caspase-Glo assay. Flow cytometry was used to analyze the cell cycle distribution and the mitochondrial membrane potential (MMP) whilst spectrophotometry was used to measure the levels of reactive oxygen species (ROS).
resultsPhytochemical analysis revealed the presence of polyphenols, triterpenes and sterols in all extracts. The IC
conclusionThis study provides evidences of the cytotoxicity of the tested plant extract and highlights the good activity of Elephantopus mollis and Kalanchoe crenata. They deserve more exploration to develop novel cytotoxic drugs.
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