Evidence map›Paper›PMID 28545501›Full record

ArticleArthritis research & therapy2017

Pregnancy-induced gene expression changes in vivo among women with rheumatoid arthritis: a pilot study.

Dana E Goin, Mette Kiel Smed, Lior Pachter, Elizabeth Purdom, J Lee Nelson, Hanne Kjærgaard, Jørn Olsen, Merete Lund Hetland, Vibeke Zoffmann, Bent Ottesen and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthritis research & therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 9 institutions in 2 countries.

Dana E GoinUCSF Benioff Children's Hospital Oakland, Children's Hospital Oakland Research Institute, 5700 Martin Luther King Jr. Way, Oakland, CA, USA.
Mette Kiel SmedJuliane Marie Center, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Lior PachterUniversity of California, Berkeley, Berkeley, CA, USA.
Elizabeth PurdomUniversity of California, Berkeley, Berkeley, CA, USA.
J Lee NelsonFred Hutchinson Cancer Research Center, Seattle, WA, USA.
Hanne KjærgaardJuliane Marie Center, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Jørn OlsenUniversity of California, Los Angeles, Los Angeles, CA, USA.
Merete Lund HetlandDANBIO Registry and Copenhagen Centre for Arthritis Research, Centre for Rheumatology and Spine Diseases (VRR), Rigshospitalet, Glostrup, Denmark.
Vibeke ZoffmannJuliane Marie Center, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Bent OttesenJuliane Marie Center, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Damini JawaheerUCSF Benioff Children's Hospital Oakland, Children's Hospital Oakland Research Institute, 5700 Martin Luther King Jr. Way, Oakland, CA, USA. djawaheer@chori.org.
Rigshospitalet · DKAarhus University · DKCalifornia Institute of Technology · USCopenhagen University Hospital · DKGlostrup Hospital · DKUCSF Benioff Children's Hospital · USUniversity of California, Berkeley · USUniversity of California, Los Angeles · USUniversity of Washington · US

Funding

Gene Expression Profiling in a Prospective Rheumatoid Arthritis Pregnancy CohortR21AR057931 · NIAMS · CHILDREN'S HOSPITAL & RES CTR AT OAKLAND · PI JAWAHEER, DAMINI · 2010 to 2011
$334k
NIAMS NIH HHS R21 AR057931
6 · The paper itself

Abstract

backgroundLittle is known about gene expression changes induced by pregnancy in women with rheumatoid arthritis (RA) and healthy women because the few studies previously conducted did not have pre-pregnancy samples available as baseline. We have established a cohort of women with RA and healthy women followed prospectively from a pre-pregnancy baseline. In this study, we tested the hypothesis that pregnancy-induced changes in gene expression among women with RA who improve during pregnancy (pregDAS

methodsGlobal gene expression profiles were generated by RNA sequencing (RNA-seq) from 11 women with RA and 5 healthy women before pregnancy (T0) and at the third trimester (T3). Among the women with RA, eight showed an improvement in disease activity by T3, whereas three worsened. Differential expression analysis was used to identify genes demonstrating significant changes in expression within each of the RA and healthy groups (T3 vs T0), as well as between the groups at each time point. Gene set enrichment was assessed in terms of Gene Ontology processes and protein networks.

resultsA total of 1296 genes were differentially expressed between T3 and T0 among the 8 pregDAS

conclusionsIn our pilot RNA-seq dataset, increased pregnancy-induced expression of type I IFN-inducible genes was observed among women with RA who improved during pregnancy, but not among women who worsened. These findings warrant further investigation into expression of these genes in RA pregnancy and their potential role in modulation of disease activity. These results are nevertheless preliminary and should be interpreted with caution until replicated in a larger sample.

Indexed as

TranscriptomeAdultArthritis, RheumatoidFemaleGene Expression ProfilingHumansPilot ProjectsPregnancyPregnancy ComplicationsGene expressionPregnancyRheumatoid arthritisRNA-seqType I interferon

Identifiers

PMID28545501
PMCPMC5445464
OpenAlexW2618467262

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.