ArticleBreast cancer research : BCR2017
Age-related terminal duct lobular unit involution in benign tissues from Chinese breast cancer patients with luminal and triple-negative tumors.
Article in Breast cancer research : BCR, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Associations of Stem Cell Markers with Lobular Involution in Benign Breast Tissue.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
- Relationship between breast tissue involution and breast cancer.Frontiers in oncology · 2025Review
- Associations between quantitative measures of mammographic density and terminal ductal lobular unit involution in Chinese breast cancer patients.Breast cancer research : BCR · 2024Article
- Reproductive Factors Related to Childbearing and a Novel Automated Mammographic Measure, V.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Article
- Benign Breast Disease and Breast Cancer Risk in the Percutaneous Biopsy Era.JAMA surgery · 2024Article
- Host, reproductive, and lifestyle factors in relation to quantitative histologic metrics of the normal breast.Breast cancer research : BCR · 2023Article
- Changes in the mammary gland during aging and its links with breast diseases.Acta biochimica et biophysica Sinica · 2023Review
- Associations between quantitative measures of TDLU involution and breast tumor molecular subtypes among breast cancer cases in the Black Women's Health Study: a case-case analysis.Breast cancer research : BCR · 2022Article
- Association of Genetic Ancestry With Terminal Duct Lobular Unit Involution Among Healthy Women.Journal of the National Cancer Institute · 2022Article
- Breast clinical target volume: HU-based glandular CTVs and ESTRO CTVs in modern and historical radiotherapy treatment planning.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2022Article
- Deep Learning Image Analysis of Benign Breast Disease to Identify Subsequent Risk of Breast Cancer.JNCI cancer spectrum · 2021Article
- Automated Quantitative Measures of Terminal Duct Lobular Unit Involution and Breast Cancer Risk.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020Article
- Breast tumor tissue inflammation but not lobular involution is associated with survival among breast cancer patients in the Multiethnic Cohort.Cancer epidemiology · 2020Article
- Polygenic risk score for the prediction of breast cancer is related to lesser terminal duct lobular unit involution of the breast.NPJ breast cancer · 2020Article
- Deep learning assessment of breast terminal duct lobular unit involution: Towards automated prediction of breast cancer risk.PloS one · 2020Article
- Involution of Breast Lobules, Mammographic Breast Density and Prognosis Among Tamoxifen-Treated Estrogen Receptor-Positive Breast Cancer Patients.Journal of clinical medicine · 2019Article
- The relationship between terminal duct lobular unit features and mammographic density among Chinese breast cancer patients.International journal of cancer · 2019Article
- Evaluation of the response of breast cancer patients to neoadjuvant chemotherapy by combined contrast-enhanced ultrasonography and ultrasound elastography.Experimental and therapeutic medicine · 2019Article
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Authors and funding
13 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundTerminal duct lobular unit (TDLU) involution is a physiological process of breast tissue aging characterized by a reduction in the epithelial component. In studies of women with benign breast disease, researchers have found that age-matched women with lower levels of TDLU involution are at increased risk of developing breast cancer. We previously showed that breast cancer cases with core basal phenotype (CBP; estrogen receptor negative [ER
methodsWe performed morphometric assessment of TDLUs by using three reproducible semiquantitative measures that inversely correlate with TDLU involution (TDLU count/100 mm
resultsOverall, we found that TN and particularly CBP cases tended to have greater TDLU measures (less involution) than luminal A cases in logistic regression models accounting for age, body mass index, parity, and tumor grade. The strongest association was observed for tertiles of acini count among younger women (aged <50 years) (CBP vs. luminal A; OR
conclusionsThese data extend previous findings that TN/CBP breast cancers are associated with reduced TDLU involution in surrounding breast parenchyma compared with luminal A cases among Chinese women, providing further support for differences in the pathogenesis of these tumor subtypes.
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