Evidence map›Paper›PMID 28545466›Full record

ArticleBMC cancer2017

Preoperative cholesterol level as a new independent predictive factor of survival in patients with metastatic renal cell carcinoma treated with cyto-reductive nephrectomy.

Hakmin Lee, Yong June Kim, Eu Chang Hwang, Seok Ho Kang, Sung-Hoo Hong, Jinsoo Chung, Tae Gyun Kwon, Cheol Kwak, Hyeon Hoe Kim, Jong Jin Oh and 5 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Hakmin LeeDepartment of Urology, Seoul National University Bundang Hospital, Seongnam, South Korea.
Yong June KimDepartment of Urology, Chungbuk National University College of Medicine, Cheongju, South Korea.
Eu Chang HwangDepartment of Urology, Chonnam National University Hwasun Hospital, Hwasun, South Korea.
Seok Ho KangDepartment of Urology, Korea University School of Medicine, Seoul, South Korea.
Sung-Hoo HongDepartment of Urology, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Jinsoo ChungDepartment of Urology, National Cancer Center, Goyang, South Korea.
Tae Gyun KwonDepartment of Urology, Kyungpook National University College of Medicine, Daegu, South Korea.
Cheol KwakDepartment of Urology, Seoul National University Hospital, Seoul, Republic of Korea.
Hyeon Hoe KimDepartment of Urology, Seoul National University Hospital, Seoul, Republic of Korea.
Jong Jin OhDepartment of Urology, Seoul National University Bundang Hospital, Seongnam, South Korea.
Sang Chul LeeDepartment of Urology, Seoul National University Bundang Hospital, Seongnam, South Korea.
Sung Kyu HongDepartment of Urology, Seoul National University Bundang Hospital, Seongnam, South Korea.
Sang Eun LeeDepartment of Urology, Seoul National University Bundang Hospital, Seongnam, South Korea.
Seok-Soo ByunDepartment of Urology, Seoul National University Bundang Hospital, Seongnam, South Korea. ssbyun@snubh.org.
KOrean Renal Cell Carcinoma (KORCC) Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe obesity and lipid metabolism were previously proposed to be related with the clinical outcomes of metastatic renal cell carcinoma (mRCC). We tried to investigate the relationship between preoperative cholesterol level (PCL) and survival outcomes in patients with mRCC.

methodsWe analysed the data of 244 patients initially treated with cyto-reductive nephrectomy after being diagnosed with mRCC. Patients were stratified into two groups according to the PCL cut-off level of 170 mg/dL. The postoperative survival rates were compared using Kaplan-Meier analysis and the possible predictors of patients' cancer-specific survival (CSS) and overall survival (OS) were tested using multivariate Cox-proportional hazard models.

resultsThe low cholesterol group showed significantly worse postoperative CSS (p = 0.013) and OS (p = 0.009) than the high cholesterol group. On multivariate analysis, low PCL was revealed as an independent predictor of worse CSS (hazard ratio [HR], 2.162; 95% CI, 1.221-3.829; p = 0.008) and OS (HR, 2.013; 95% CI, 1.206-3.361; p = 0.007). Subsequent subgroup analysis showed that these results were maintained in the clear cell subgroup but not in the non-clear cell subgroup.

conclusionDecreased PCL was significantly correlated with worse survival outcomes in patients with mRCC treated with cytoreductive nephrectomy. The underlined mechanism is still uncharted and requires further investigation.

Indexed as

Cytoreduction Surgical ProceduresNephrectomyAgedCarcinoma, Renal CellCholesterolHumansKaplan-Meier EstimateKidney NeoplasmsMiddle AgedNeoplasm MetastasisProportional Hazards ModelsRepublic of KoreaRetrospective StudiesSurvival RateCholesterolCholesterolHypercholesterolemiaMetastasisRenal cell carcinomaSurvival

Identifiers

PMID28545466
PMCPMC5445323

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