ArticleCanadian journal of psychiatry. Revue canadienne de psychiatrie2017
Psychotropic Drug Use before, during, and after Pregnancy: A Population-Based Study in a Canadian Cohort (2001-2013).
Article in Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Pregnancy and Delivery Outcomes Following Benzodiazepine Exposure: A Systematic Review and Meta-analysis.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2020Pooled it
- Treatment of depression, anxiety, and trauma-related disorders during the perinatal period: A systematic review.Clinical psychology review · 2018Pooled it
- A randomized controlled trial of an electronic patient decision aid (PDA) for decision-making around antidepressant use in pregnancy.Archives of women's mental health · 2026Trial
- Preferences, factors, and needs involved in decision-making on medication use during lactation among parents and healthcare providers: a Canada-wide cross-sectional survey study.International breastfeeding journal · 2026Article
- The Management of Perinatal Borderline Personality Disorder.Journal of clinical medicine · 2023Review
- Antipsychotic utilization patterns in pregnant women with psychotic disorders: a 16-year population-based cohort study.European archives of psychiatry and clinical neuroscience · 2023Article
- Use of Medication to Treat Attention-Deficit/Hyperactivity Disorder in Young Children: The Role of Maternal History of Psychotropic Medication Use.Child psychiatry and human development · 2023Article
- The role of prenatal exposure to antidepressants, anxiolytic, and hypnotics and its underlying illness on the risk of miscarriage using BIFAP database.Pharmacoepidemiology and drug safety · 2022Article
- Obstetric complications in mothers with ADHD.Frontiers in reproductive health · 2022Article
- Prevalence and determinants of attention deficit/hyperactivity disorder (ADHD) medication use during pregnancy: Results from the Quebec Pregnancy/Children Cohort.Pharmacology research & perspectives · 2021Article
- Perinatal mental health: a review of progress and challenges.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2020Article
- Patterns of antidepressant use during pregnancy: a nationwide population-based cohort study.British journal of clinical pharmacology · 2018Article
- Weighing the Risks: the Management of Bipolar Disorder During Pregnancy.Current psychiatry reports · 2018Review
- Could changes in pharmacotherapy peripregnancy contribute to the shift in means of suicide?CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2017Article
- The Perinatal Treatment Conundrum.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo describe the extent of increase in use and the rate of continuation versus discontinuation of psychotropic agents before, during, and after pregnancy.
methodsRates of psychotropic use (antidepressants, anxiolytic/sedative-hypnotics, antiepileptics, antipsychotics, lithium, stimulants) among women with a hospital-recorded pregnancy outcome were assessed using databases at the Manitoba Centre for Health Policy. Rate of use was defined as ≥1 prescription over the total number of pregnancies in the 3-12 months before pregnancy, 0-3 months before pregnancy, during pregnancy, or 3 months after pregnancy. Continued use was defined as ≥2 prescriptions with gap ≤14 days. Poisson regression was used to analyze trends.
resultsOver the study period, a psychotropic drug was used before, during, or after pregnancy in 41,923 of 224,762 pregnancies. From 2001 to 2013, psychotropic use increased 1.5-fold from 11.1% to 16.2% ( p < 0.0001) in the 3-12 months before pregnancy, 1.6-fold from 6.4% to 10.5% ( p < 0.0001) in the 3 months before pregnancy, 1.8-fold from 3.3% to 6.0% ( p < 0.0001) during pregnancy, and 1.5-fold from 6.2% to 9.5% ( p < 0.0001) in the 3 months postpartum. Among the 13,579 women who received at least 1 psychotropic agent in the 3 months prior to pregnancy, 38.5% stopped the agent prior to pregnancy and only 10.3% continued use throughout pregnancy. Continued use throughout pregnancy was higher (56.9%) among the 6693 women who received at least 2 prescriptions for a psychotropic agent and were at least 80% adherent in the 3 months prior to pregnancy.
conclusionThe use of psychotropic agents increased over 12 years. The safety of continuing versus discontinuing these agents during pregnancy remains uncertain, but we observed a decrease in psychotropic drug use during the pregnancy period.
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