ArticlePloS one2017
The dynamic behaviour of metabolic syndrome and its components in an eight-year population-based cohort from the Mediterranean.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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10 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Dynamic behavior of metabolic syndrome progression: a comprehensive systematic review on recent discoveries.BMC endocrine disorders · 2021Pooled it
- A Longitudinal Assessment of Metabolic Syndrome.Journal of clinical medicine · 2025Article
- The role of changes in metabolic syndrome status on health-related quality of life in Bogor City, West Java, Indonesia: A cross-sectional study.Belitung nursing journal · 2025Article
- Pregnancy homocysteine and cobalamin status predict childhood metabolic health in the offspring.Pediatric research · 2023Article
- The dynamics of metabolic syndrome development from its isolated components among Iranian adults: findings from 17 years of the Tehran lipid and glucose study (TLGS).Journal of diabetes and metabolic disorders · 2021Article
- Dynamic Changes of Metabolic Syndrome Alter the Risks of Cardiovascular Diseases and All-Cause Mortality: Evidence From a Prospective Cohort Study.Frontiers in cardiovascular medicine · 2021Article
- Article
- Association of Changes in Metabolic Syndrome Status With the Incidence of Thyroid Nodules: A Prospective Study in Chinese Adults.Frontiers in endocrinology · 2020Article
- Association of Variability in Body Mass Index and Metabolic Health With Cardiometabolic Disease Risk.Journal of the American Heart Association · 2019Article
- Dynamic development of metabolic syndrome and its risk prediction in Chinese population: a longitudinal study using Markov model.Diabetology & metabolic syndrome · 2018Article
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Authors and funding
4 authors at 2 institutions in 1 country.
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Abstract
backgroundThe significant rise in the prevalence of obesity coincides with the considerable increase in the prevalence of metabolic syndrome (MS) currently being observed worldwide. The components of MS are not static and their dynamics, such as the order of their occurrence, or the time of exposure to them are, as yet, unknown but could well be clinically relevant. Our objective was to study the dynamic behaviour of MS and its components in a large population-based cohort from a Mediterranean region. METHODS AND
findingsOur study employed a retrospective cohort (between January 1, 2005 and December 31, 2012) made up of individuals from the general population in a region in the northeast of Catalonia, Spain. Given that most of the explicative variables of the risk of having MS were time dependent and, therefore, the risk was not proportional, we used the Andersen-Gill (AG) model to perform a multivariate survival analysis and inferences were performed using a Bayesian framework. Thirty-nine percent of the participants developed MS; 44.6% of them with a single limited episode. Triglycerides and low HDL cholesterol, together with obesity, are components associated with the first occurrence of MS. Components related to the metabolism of glucose are associated with a medium risk of having a first episode of MS, and those related to blood pressure are associated with a lower risk. When the components related to blood pressure and the metabolism of glucose appear first, they determine the appearance of the first episode of MS. The variables concerning the persistence of MS are those that correspond to clinical conditions that do not have well-established drug treatment criteria.
conclusionsOur results suggest that the components related to the metabolism of glucose and to high blood pressure appear early on and act as biomarkers for predicting MS, while the components related to obesity and dyslipidaemia, although essential for the development of MS, appear later. Making lifestyle changes reduces the conditions associated with the persistence of MS.
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