ArticlePloS one2017
Influence of the ferric uptake regulator (Fur) protein on pathogenicity in Pectobacterium carotovorum subsp. brasiliense.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Compensatory evolution of chromosomes and plasmids counteracts the plasmid fitness cost.Ecology and evolution · 2024Article
- Manuka Honey Inhibits Biofilm Formation and Reduces the Expression of the Associated Genes inScientifica · 2024Article
- An OFrontiers in microbiology · 2023Article
- Negatively Regulated Aerobactin and Desferrioxamine E by Fur in Pantoea ananatis Are Required for Full Siderophore Production and Antibacterial Activity, but Not for Virulence.Applied and environmental microbiology · 2022Article
- Biosynthesis Pathways, Transport Mechanisms and Biotechnological Applications of Fungal Siderophores.Journal of fungi (Basel, Switzerland) · 2021Review
- Functional characterization of Fur in iron metabolism, oxidative stress resistance and virulence of Riemerella anatipestifer.Veterinary research · 2021Article
- Article
- Ferric Uptake Regulator Fur Coordinates Siderophore Production and Defense against Iron Toxicity and Oxidative Stress and Contributes to Virulence in Chromobacterium violaceum.Applied and environmental microbiology · 2020Article
- Article
- Fur RepressesFrontiers in microbiology · 2020Article
- Transcriptome and Comparative Genomics Analyses Reveal New Functional Insights on Key Determinants of Pathogenesis and Interbacterial Competition inApplied and environmental microbiology · 2019Article
- The Impact of Type VI Secretion System, Bacteriocins and Antibiotics on Bacterial Competition ofFrontiers in microbiology · 2019Article
- Fur regulation of Staphylococcus aureus heme oxygenases is required for heme homeostasis.International journal of medical microbiology : IJMM · 2018Article
- Bacterial iron acquisition mediated by outer membrane translocation and cleavage of a host protein.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Transcriptome Profiling Reveals the EanI/R Quorum Sensing Regulon in Pantoea Ananatis LMG 2665Genes · 2018Article
- How Does the Sweet Violet (Frontiers in plant science · 2018Article
- Integration of Transcriptomic and Proteomic Approaches Reveals the Temperature-Dependent Virulence ofFrontiers in cellular and infection microbiology · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Iron is an important nutrient for the survival and growth of many organisms. In order to survive, iron uptake from the environment must be strictly regulated and maintained to avoid iron toxicity. The ferric uptake regulator protein (Fur) regulates genes involved in iron homeostasis in many bacteria, including phytopathogens. However, to date, the role played by Fur in the biology of Pectobacterium carotovorum subsp. brasiliense (Pcb1692), an important pathogen of potatoes, has not yet been studied. To this end, we used the lambda recombineering method to generate a fur mutant strain of Pcb1692 and assessed the virulence and fitness of the mutant strain. The results showed that production of siderophores in Pcb1692Δfur increased compared to the Pcb1692 wild-type and the complemented strain Pcb1692Δfur-pfur. However, production of N-acyl homoserine lactone (AHLs), biofilm formation, exopolysaccharide (EPS) production, virulence on potato tubers and swimming motility, were all significantly decreased in Pcb1692Δfur compared to the wild-type and complemented Pcb1692Δfur-pfur strains. The Pcb1692Δfur mutant also demonstrated significant sensitivity to oxidative stress when exposed to H2O2. Consistent with phenotypic results, qRT-PCR results demonstrated that Fur down-regulates genes which encode proteins associated with: iron uptake (HasA-extracellular heme-binding protein and Ferrodoxin-AED-0004132), stress response (SodC-superoxide dismutase), plant cell wall degrading enzymes (PrtA and CelV) and motility (FlhC and MotA). We conclude that the ferric uptake regulator protein (Fur) of Pcb1692 regulates traits that are important to host-pathogens interactions.
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