ArticlePloS one2017
BRL3 and AtRGS1 cooperate to fine tune growth inhibition and ROS activation.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
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- Comprehensive analysis of sesame LRR-RLKs: structure, evolution and dynamic expression profiles underFrontiers in plant science · 2024Article
- Receptor-like Kinases (LRR-RLKs) in Response of Plants to Biotic and Abiotic Stresses.Plants (Basel, Switzerland) · 2022Review
- G-Protein Phosphorylation: Aspects of Binding Specificity and Function in the Plant Kingdom.International journal of molecular sciences · 2022Review
- An Anecdote on Prospective Protein Targets for Developing Novel Plant Growth Regulators.Molecular biotechnology · 2022Review
- Transcriptome Analysis ofPlants (Basel, Switzerland) · 2021Article
- Evolutionary analysis and functional characterization of SiBRI1 as a Brassinosteroid receptor gene in foxtail millet.BMC plant biology · 2021Article
- Sugar inhibits brassinosteroid signaling by enhancing BIN2 phosphorylation of BZR1.PLoS genetics · 2021Article
- Linking Brassinosteroid and ABA Signaling in the Context of Stress Acclimation.International journal of molecular sciences · 2020Review
- Brassinosteroid signaling in plant development and adaptation to stress.Development (Cambridge, England) · 2019Review
- Network biology discovers pathogen contact points in host protein-protein interactomes.Nature communications · 2018Article
- Ligand-triggered de-repression of Arabidopsis heterotrimeric G proteins coupled to immune receptor kinases.Cell research · 2018Article
- Long-distance communication in Arabidopsis involving a self-activating G protein.Plant direct · 2018Article
- UDP-Glucose: A Potential Signaling Molecule in Plants?Frontiers in plant science · 2017Article
- Predicted Functional Implications of Phosphorylation of Regulator of G Protein Signaling Protein in Plants.Frontiers in plant science · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Plasma membrane-localized leucine-rich repeat receptor-like kinases directly activates G protein complex via interaction with seven transmembrane domain Regulator of G-protein Signaling 1 (AtRGS1) protein. Brassinosteroid insensitive 1 (BRI1) LIKE3 (BRL3) phosphorylates AtRGS1 in vitro. FRET analysis showed that BRL3 and AtRGS1 interaction dynamics change in response to glucose and flg22. Both BRL3 and AtRGS1 function in glucose sensing and brl3 and rgs1-2 single mutants are hyposensitive to high glucose as well as the brl3/rgs1 double mutant. BRL3 and AtRGS1 function in the same pathway linked to high glucose sensing. Hypocotyl elongation, another sugar-mediated pathway, is also implicated to be partially mediated by BRL3 and AtRGS1 because rgs1-2, brl3-2 and brl3-2/ rgs1-2 mutants share the long hypocotyl phenotype. BRL3 and AtRGS1 modulate the flg22-induced ROS burst and block one or more components positively regulating ROS production because the brl3/rgs1 double mutant has ~60% more ROS production than wild type while rgs1-2 has a partial ROS burst impairment and brl3 has slightly more ROS production. Here, we proposed a simple model where both BRL3 and AtRGS1 are part of a fine-tuning mechanism sensing glucose and flg22 to prevent excess ROS burst and control growth inhibition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.