ArticlePloS one2017
Increased risk for diabetes development in subjects with large variation in total cholesterol levels in 2,827,950 Koreans: A nationwide population-based study.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- A nomogram for predicting 5-year incidence of type 2 diabetes in a Chinese population.Endocrine · 2020Trial
- The U.S. diabetes belt and factors explaining the excess risk: Multifactorial modeling and machine learning analysis.Primary care diabetes · 2026Article
- Association of a novel index, the total cholesterol-high-density lipoprotein-glucose index, with diabetes mellitus in Chinese adults: a retrospective cohort study.Frontiers in endocrinology · 2026Article
- Cholesterol-HDL-glucose index and type 2 diabetes risk in middle-aged and older adults: Evidence from a nationwide Chinese cohort.Medicine · 2025Observational
- Association between the cholesterol, high-density lipoprotein, and glucose index and type 2 diabetes mellitus prevalence in US adults: A cross-sectional study based on National Health and Nutrition Examination Survey 2009-2018.The Journal of international medical research · 2025Article
- Biochemical Profile Variations Among Type 2 Diabetic Patients Stratified by Hemoglobin A1c Levels in a Saudi Cohort: A Retrospective Study.Journal of clinical medicine · 2025Article
- Multi-modal analyses of proteomic measurements associated with type 2 diabetes from the Project Baseline Health Study.Communications medicine · 2025Article
- A novel index for diagnosis of type 2 diabetes mellitus: Cholesterol, High density lipoprotein, and Glucose (CHG) index.Journal of diabetes investigation · 2025Article
- Investigating causal networks of dementia using causal discovery and natural language processing models.NPJ dementia · 2025Article
- Association of variability in metabolic parameters with the incidence of type 2 diabetes: evidence from a functional community cohort.Cardiovascular diabetology · 2023Article
- Associations of Clusters of Cardiovascular Risk Factors with Insulin Resistance and Β-Cell Functioning in a Working-Age Diabetic-Free Population in Kazakhstan.International journal of environmental research and public health · 2023Article
- Machine learning models for prediction of co-occurrence of diabetes and cardiovascular diseases: a retrospective cohort study.Journal of diabetes and metabolic disorders · 2022Article
- Identification of Insulin Resistance Biomarkers in Metabolic Syndrome Detected by UHPLC-ESI-QTOF-MS.Metabolites · 2022Article
- Temporal sequence of blood lipids and insulin resistance in perimenopausal women: the study of women's health across the nation.BMJ open diabetes research & care · 2022Article
- The Influence of Obesity and Metabolic Health on Vascular Health.Endocrinology and metabolism (Seoul, Korea) · 2022Review
- Prevalence and characteristics associated with diabetes mellitus and impaired fasting glucose among people aged 15 to 64 years in rural and urban Rwanda: secondary data analysis of World Health Organization surveillance data.The Pan African medical journal · 2022Article
- Analysis of blood lipid changes and influencing factors in physical examination population of a city in central China.Frontiers in cardiovascular medicine · 2022Article
- Increased Visit-to-Visit Liver Enzyme Variability Is Associated with Incident Diabetes: A Community-Based 12-Year Prospective Cohort Study.Diabetes & metabolism journal · 2021Article
- Triglyceride to high-density lipoprotein cholesterol ratio variability and incident diabetes: A 7-year prospective study in a Chinese population.Journal of diabetes investigation · 2021Article
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Abstract
backgroundRecent studies suggest a role for hyperlipidemia in the development of diabetes. The aim of this study is to analyze the relationship between variations of total cholesterol (TC) levels and the risk for type 2 diabetes development from a Korean nationwide population-based database. MATERIALS AND
methodsWe examined the General Health Check-up sub-dataset of the Korean National Health Insurance Service (NHIS) of 2,827,950 participants who had at least three health check-ups between 2002 and 2007, and were not reported to have diabetes during that time. The variations of TC levels between the examinations were calculated as follows: [Formula: see text]. The examinees were divided into 10 groups according to TC variation, and the hazard ratio for diabetes development from 2007 to 2013, were analyzed.
resultsDuring the follow-up period, 3.4% of the participants had developed diabetes. The hazard ratio (HR) for diabetes development relative to the overall risk in the whole study population started to be higher than 1.0 from eighth decile of TC variation. The highest decile group showed an increased HR for diabetes development after adjustment for confounding variables (1.139; 95% confidence interval 1.116~1.163). These results were similar regardless of the use of anti-hyperlipidemic medication and baseline TC levels.
conclusionsThe participants with a large variation in TC levels showed an increased risk for diabetes development, independent of the use of anti-hyperlipidemic medications. These results suggest a relationship between fluctuations in lipid levels and the development of type 2 diabetes.
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