ArticleCell systems2017
The Limiting-Pool Mechanism Fails to Control the Size of Multiple Organelles.
Article in Cell systems, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Tubulin autoregulation tunes microtubule dynamics to support multicellular architecture and viability.Nature communications · 2026Article
- An adaptable, self-organizing, single-cell morphology circuit optimizes suctorian predatory trap structure.Current biology : CB · 2026Article
- Mitotic Cdc42 waves encode PI(3,4)PScience advances · 2026Article
- Distinct disassembly modes shape cytoskeletal assembly and fluctuations.Biophysical reports · 2026Article
- Quantitative Signatures of Disassembly Mechanisms Modulating Filament and Bundle Assembly in a Shared Pool.bioRxiv : the preprint server for biology · 2025Article
- Design principles and feedback mechanisms in organelle size control.Current opinion in cell biology · 2025Review
- Transcription-templated assembly of the nucleolus in theProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Reconstituted systems for studying the architecture and dynamics of actin networks.The Biochemical journal · 2025Review
- Catalytic growth in a shared enzyme pool ensures robust control of centrosome size.bioRxiv : the preprint server for biology · 2024Article
- Eukaryotic cell size regulation and its implications for cellular function and dysfunction.Physiological reviews · 2024Review
- NAGPKin: Nucleation-and-growth parameters from the kinetics of protein phase separation.Molecular biology of the cell · 2024Article
- Role of intraflagellar transport in transcriptional control during flagellar regeneration inMolecular biology of the cell · 2023Article
- Robustness and Universality in Organelle Size Control.Physical review letters · 2023Article
- Biochemical and mechanical regulation of actin dynamics.Nature reviews. Molecular cell biology · 2022Review
- Emergence and maintenance of variable-length actin filaments in a limiting pool of building blocks.Biophysical journal · 2022Article
- Size regulation of multiple organelles competing for a limiting subunit pool.PLoS computational biology · 2022Article
- Effects of random hydrolysis on biofilament length distributions in a shared subunit pool.Biophysical journal · 2022Article
- Effects of length-dependent positive feedback on length distributions of microtubules undergoing hydrolysis.Journal of biosciences · 2022Article
- Article
- The role of mode switching in a population of actin polymers with constraints.Journal of mathematical biology · 2021Article
Corrections and comments
- Commented on by
Authors and funding
5 authors.
Funding
Abstract
How the size of micrometer-scale cellular structures such as the mitotic spindle, cytoskeletal filaments, the nucleus, the nucleolus, and other non-membrane bound organelles is controlled despite a constant turnover of their constituent parts is a central problem in biology. Experiments have implicated the limiting-pool mechanism: structures grow by stochastic addition of molecular subunits from a finite pool until the rates of subunit addition and removal are balanced, producing a structure of well-defined size. Here, we consider these dynamics when multiple filamentous structures are assembled stochastically from a shared pool of subunits. Using analytical calculations and computer simulations, we show that robust size control can be achieved only when a single filament is assembled. When multiple filaments compete for monomers, filament lengths exhibit large fluctuations. These results extend to three-dimensional structures and reveal the physical limitations of the limiting-pool mechanism of size control when multiple organelles are assembled from a shared pool of subunits.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.