ArticleBipolar disorders2017
Similar familial underpinnings for full and subsyndromal pediatric bipolar disorder: A familial risk analysis.
Article in Bipolar disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The morbidity of subthreshold pediatric bipolar disorder: A systematic literature review and meta-analysis.Bipolar disorders · 2019Pooled it
- Findings from a pilot open-label trial of N-acetylcysteine for the treatment of pediatric mania and hypomania.BMC psychiatry · 2022Trial
- Pediatric Bipolar Disorder: Challenges in Diagnosis and Treatment.Paediatric drugs · 2025Review
- Long term outcomes of pediatric Bipolar-I disorder: A prospective follow-up analysis attending to full syndomatic, subsyndromal and functional types of remission.Journal of psychiatric research · 2022Article
- Toward prevention of bipolar disorder in at-risk children: Potential strategies ahead of the data.Journal of affective disorders · 2020Review
- A Risk Calculator to Predict the Individual Risk of Conversion From Subthreshold Bipolar Symptoms to Bipolar Disorder I or II in Youth.Journal of the American Academy of Child and Adolescent Psychiatry · 2018Article
- Further evidence of high level of persistence of pediatric bipolar-I disorder from childhood onto young adulthood: a five-year follow up.Scandinavian journal of child and adolescent psychiatry and psychology · 2018Article
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Authors and funding
9 authors.
Funding
Abstract
objectivesTo examine the validity of subthreshold pediatric bipolar I disorder (BP-I), we compared the familial risk for BP-I in the child probands who had either full BP-I, subthreshold BP-I, ADHD, or were controls that neither had ADHD nor bipolar disorder.
methodsBP-I probands were youth aged 6-17 years meeting criteria for BP-I, full (N=239) or subthreshold (N=43), and also included were their first-degree relatives (N=687 and N=120, respectively). Comparators were youth with ADHD (N=162), controls without ADHD or bipolar disorder (N=136), and their first-degree relatives (N=511 and N=411, respectively). We randomly selected 162 non-bipolar ADHD probands and 136 non-bipolar, non-ADHD control probands of similar age and sex distribution to the BP-I probands from our case-control ADHD family studies. Psychiatric assessments were made by trained psychometricians using the Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children Epidemiological Version (KSADS-E) and Structured Clinical Interview for DSM-IV (SCID) structured diagnostic interviews. We analyzed rates of bipolar disorder using multinomial logistic regression.
resultsRates of full BP-I significantly differed between the four groups (χ
conclusionsOur results showed that youth with subthreshold BP-I had similarly elevated risk for BP-I and major depressive disorder in first-degree relatives as youth with full BP-I. These findings support the diagnostic continuity between subsyndromal and fully syndromatic states of pediatric BP-I disorder.
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