Evidence map›Paper›PMID 28544650›Full record

ReviewBirth defects research2017

Diverse application of MRI for mouse phenotyping.

Yijen L Wu, Cecilia W Lo

Abstract readReview
In one paragraph

Review in Birth defects research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Genome Editing and Myocardial Development.Advances in experimental medicine and biology · 2023
    Review
  4. Article
  5. Comprehensive Volumetric Analysis ofFrontiers in neuroscience · 2022
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Yijen L WuDepartment of Developmental Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.ORCID http://orcid.org/0000-0001-9509-5417
Cecilia W LoDepartment of Developmental Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Funding

Modeling the genetic basis for human congenital heart disease in miceU01HL098180 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LO, CECILIA W. · 2009 to 2014
$8.5M
Modeling the complex genetics of congenital heart disease in miceR01HL132024 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LO, CECILIA W. · 2016 to 2019
$3.4M
Assaying Heterotaxy Patient Genes in Cilia Motility and Left-Right PatterningR01GM104412 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHENNUBHOTLA, SRINIVAS CHAKRA, LO, CECILIA W. · 2014 to 2017
$2.4M
Confocal enhanced episcopic fluorescent image capture (EFIC)S10OD010340 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LO, CECILIA W. · 2012 to 2012
$368k
NHLBI NIH HHS R01 HL132024NHLBI NIH HHS U01 HL098180NIGMS NIH HHS R01 GM104412NIH HHS S10 OD010340
6 · The paper itself

Abstract

Small animal models, particularly mouse models, of human diseases are becoming an indispensable tool for biomedical research. Studies in animal models have provided important insights into the etiology of diseases and accelerated the development of therapeutic strategies. Detailed phenotypic characterization is essential, both for the development of such animal models and mechanistic studies into disease pathogenesis and testing the efficacy of experimental therapeutics. MRI is a versatile and noninvasive imaging modality with excellent penetration depth, tissue coverage, and soft tissue contrast. MRI, being a multi-modal imaging modality, together with proven imaging protocols and availability of good contrast agents, is ideally suited for phenotyping mutant mouse models. Here we describe the applications of MRI for phenotyping structural birth defects involving the brain, heart, and kidney in mice. The versatility of MRI and its ease of use are well suited to meet the rapidly increasing demands for mouse phenotyping in the coming age of functional genomics. Birth Defects Research 109:758-770, 2017. © 2017 Wiley Periodicals, Inc.

Indexed as

AnimalsBrainCongenital AbnormalitiesContrast MediaDisease Models, AnimalHeartKidneyMagnetic Resonance ImagingMicePhenotypeContrast Mediabraincongenital malformationdiffusion tensor imagingheartkidneymagnetic resonance ImagingmouseMRImutanttagging

Identifiers

PMID28544650
PMCPMC5738275

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.