ArticleJournal of experimental zoology. Part B, Molecular and developmental evolution2017
Spotted Gar and the Evolution of Innate Immune Receptors.
Article in Journal of experimental zoology. Part B, Molecular and developmental evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Holostean genomes reveal evolutionary novelty in the vertebrate immunoproteasome that have implications for MHCI function.Molecular biology and evolution · 2026Article
- Ancient fish lineages illuminate toll-like receptor diversification in early vertebrate evolution.Immunogenetics · 2023Article
- The amphibian immune system.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- A highly diverse set of novel immunoglobulin-like transcript (NILT) genes in zebrafish indicates a wide range of functions with complex relationships to mammalian receptors.Immunogenetics · 2023Article
- Placing human gene families into their evolutionary context.Human genomics · 2022Review
- Transcriptome annotation reveals minimal immunogenetic diversity among Wyoming toads,Conservation genetics (Print) · 2022Article
- On the relationship between extant innate immune receptors and the evolutionary origins of jawed vertebrate adaptive immunity.Immunogenetics · 2022Review
- Secreted immunoglobulin domain effector molecules of invertebrates and management of gut microbial ecology.Immunogenetics · 2022Review
- Holosteans contextualize the role of the teleost genome duplication in promoting the rise of evolutionary novelties in the ray-finned fish innate immune system.Immunogenetics · 2021Article
- The bowfin genome illuminates the developmental evolution of ray-finned fishes.Nature genetics · 2021Article
- Article
- Review
- Olfactomedin-like 2 A and B (OLFML2A and OLFML2B) profile expression in the retina of spotted gar (Lepisosteus oculatus) and bioinformatics mining.Fish physiology and biochemistry · 2019Article
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Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
Abstract
The resolution of the gar genome affords an opportunity to examine the diversification and functional specialization of immune effector molecules at a distant and potentially informative point in phylogenetic development. Although innate immunity is effected by a particularly large number of different families of molecules, the focus here is to provide detailed characterization of several families of innate receptors that are encoded in large multigene families, for which orthologous forms can be identified in other species of bony fish but not in other vertebrate groups as well as those for which orthologs are present in other vertebrate species. The results indicate that although teleost fish and the gar, as a holostean reference species, share gene families thought previously to be restricted to the teleost fish, the manner in which the members of the multigene families of innate immune receptors have undergone diversification is different in these two major phylogenetic radiations. It appears that both the total genome duplication and different patterns of genetic selection have influenced the derivation and stabilization of innate immune genes in a substantial manner during the course of vertebrate evolution.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.