ArticleAngewandte Chemie (International ed. in English)2017
Strain Stiffening Hydrogels through Self-Assembly and Covalent Fixation of Semi-Flexible Fibers.
Article in Angewandte Chemie (International ed. in English), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Fiber-integrated hydrogels: a versatile platform to improve structural and biological performance in 3D biofabrication.Materials today. Bio · 2026Review
- Programming Hydrogel Mechanics via Sequence-Controlled Polymerization Using Peptide Self-Assembly.Journal of the American Chemical Society · 2026Article
- Emerging Smart and Adaptive Hydrogels for Next-Generation Tissue Engineering.Bioengineering (Basel, Switzerland) · 2025Review
- Chemo-Enzymatic Synthesis of Viscoelastic Pseudopeptidoglycan Networks.Bioconjugate chemistry · 2025Article
- Designing Dynamic Hydrogels: The Interplay of Cross-Linker Length, Valency, and Reaction Kinetics in Hydrazone-Based Networks.Chemistry of materials : a publication of the American Chemical Society · 2025Article
- Using a Supramolecular Monomer Formulation Approach to Engineer Modular, Dynamic Microgels, and Composite Macrogels.Advanced materials (Deerfield Beach, Fla.) · 2024Article
- Synthetic, multi-dynamic hydrogels by uniting stress-stiffening and supramolecular polymers.Science advances · 2024Article
- Well-Defined Synthetic Copolymers with Pendant Aldehydes Form Biocompatible Strain-Stiffening Hydrogels and Enable Competitive Ligand Displacement.Journal of the American Chemical Society · 2024Article
- Using Chemistry To Recreate the Complexity of the Extracellular Matrix: Guidelines for Supramolecular Hydrogel-Cell Interactions.Journal of the American Chemical Society · 2024Review
- Hepatic Spheroid Formation on Carbohydrate-Functionalized Supramolecular Hydrogels.Biomacromolecules · 2023Article
- Photo-Crosslinked Coumarin-Containing Bis-Urea Amphiphile Hydrogels.Gels (Basel, Switzerland) · 2022Article
- Spatial and Temporal Modulation of Cell Instructive Cues in a Filamentous Supramolecular Biomaterial.ACS applied materials & interfaces · 2022Article
- Tuning Strain Stiffening of Protein Hydrogels by Charge Modification.International journal of molecular sciences · 2022Article
- Cell-matrix reciprocity in 3D culture models with nonlinear elasticity.Bioactive materials · 2022Review
- Synthetic hydrogels as blood clot mimicking wound healing materials.Progress in biomedical engineering (Bristol, England) · 2021Article
- Astral hydrogels mimic tissue mechanics by aster-aster interpenetration.Nature communications · 2021Article
- Elucidating dynamic behavior of synthetic supramolecular polymers in water by hydrogen/deuterium exchange mass spectrometry.Journal of polymer science (2020) · 2021Article
- Strain Stiffening and Negative Normal Force of Agarose Hydrogels.Macromolecules · 2020Article
- Mechanochemical Adhesion and Plasticity in Multifiber Hydrogel Networks.Advanced materials (Deerfield Beach, Fla.) · 2020Article
- Highly Sensitive Polydiacetylene Ensembles for Biosensing and Bioimaging.Frontiers in chemistry · 2020Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biomimetic, strain-stiffening materials are reported, made through self-assembly and covalent fixation of small building blocks to form fibrous hydrogels that are able to stiffen by an order of magnitude in response to applied stress. The gels consist of semi-flexible rodlike micelles of bisurea bolaamphiphiles with oligo(ethylene oxide) (EO) outer blocks and a polydiacetylene (PDA) backbone. The micelles are fibers, composed of 9-10 ribbons. A gelation method based on Cu-catalyzed azide-alkyne cycloaddition (CuAAC), was developed and shown to lead to strain-stiffening hydrogels with unusual, yet universal, linear and nonlinear stress-strain response. Upon gelation, the X-ray scattering profile is unchanged, suggesting that crosslinks are formed at random positions along the fiber contour without fiber bundling. The work expands current knowledge about the design principles and chemistries needed to achieve fully synthetic, biomimetic soft matter with on-demand, targeted mechanical properties.
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Registered trials
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