ArticleAging cell2017
Impairment of insulin signalling in peripheral tissue fails to extend murine lifespan.
Article in Aging cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Involvement of a battery of investigated genes in lipid droplet pathophysiology and associated comorbidities.Adipocyte · 2024Review
- A naturally occurring polyacetylene isolated from carrots promotes health and delays signatures of aging.Nature communications · 2023Article
- Changes of Signaling Pathways in Hypothalamic Neurons with Aging.Current issues in molecular biology · 2023Review
- Transcriptome Analysis Reveals the Molecular Basis of Overfeeding-Induced Diabetes in Zebrafish.International journal of molecular sciences · 2023Article
- Lifespan-extending interventions induce consistent patterns of fatty acid oxidation in mouse livers.Communications biology · 2023Article
- Extracellular Matrix Dynamics as an Emerging yet Understudied Hallmark of Aging and Longevity.Aging and disease · 2023Review
- Lack of adipocyte IP3R1 reduces diet-induced obesity and greatly improves whole-body glucose homeostasis.Cell death discovery · 2023Article
- FOXO3A-short is a novel regulator of non-oxidative glucose metabolism associated with human longevity.Aging cell · 2023Article
- Reduced insulin signaling in neurons induces sex-specific health benefits.Science advances · 2023Article
- Dietary supplementation of clinically utilized PI3K p110α inhibitor extends the lifespan of male and female mice.Nature aging · 2023Article
- Rapamycin/metformin co-treatment normalizes insulin sensitivity and reduces complications of metabolic syndrome in type 2 diabetic mice.Aging cell · 2022Article
- Insulin-like growth factor I sensitization rejuvenates sleep patterns in old mice.GeroScience · 2022Article
- The Less We Eat, the Longer We Live: Can Caloric Restriction Help Us Become Centenarians?International journal of molecular sciences · 2022Review
- Mitochondrial and metabolic dysfunction in ageing and age-related diseases.Nature reviews. Endocrinology · 2022Review
- The aetiology and molecular landscape of insulin resistance.Nature reviews. Molecular cell biology · 2021Review
- Aging modulated by the Drosophila insulin receptor through distinct structure-defined mechanisms.Genetics · 2021Article
- Efficacy of Providing the PI3K p110α Inhibitor BYL719 (Alpelisib) to Middle-Aged Mice in Their Diet.Biomolecules · 2021Article
- Perspective: Methionine Restriction-Induced Longevity-A Possible Role for Inhibiting the Synthesis of Bacterial Quorum Sensing Molecules.Advances in nutrition (Bethesda, Md.) · 2020Article
- Partial impairment of insulin receptor expression mimics fasting to prevent diet-induced fatty liver disease.Nature communications · 2020Article
- Mitochondria in the signaling pathways that control longevity and health span.Ageing research reviews · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 4 countries.
Funding
Abstract
Impaired insulin/IGF1 signalling has been shown to extend lifespan in model organisms ranging from yeast to mammals. Here we sought to determine the effect of targeted disruption of the insulin receptor (IR) in non-neuronal tissues of adult mice on the lifespan. We induced hemizygous (PerIRKO
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.