ArticleJournal of biomedical materials research. Part A2017
Galectin-1 promotes an M2 macrophage response to polydioxanone scaffolds.
Article in Journal of biomedical materials research. Part A, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Healing mechanisms of Galectin-1 in the ischemic heart.Cell biochemistry and biophysics · 2026Review
- The Immunomodulatory Role of Galectin-1 in the Tumour Microenvironment and Strategies for Therapeutic Applications.Cancers · 2025Review
- Biological responses to biomaterials: a review.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2025Review
- Single-cell analysis defines LGALS1+ fibroblasts that promote proliferation and migration of intrahepatic cholangiocarcinoma.Journal of molecular cell biology · 2024Article
- Tregs delivered post-myocardial infarction adopt an injury-specific phenotype promoting cardiac repair via macrophages in mice.Nature communications · 2024Article
- Article
- Mapping the tumor microenvironment in clear cell renal carcinoma by single-cell transcriptome analysis.Frontiers in genetics · 2023Article
- Galectokines: The Promiscuous Relationship between Galectins and Cytokines.Biomolecules · 2022Review
- Single-cell assessment of the modulation of macrophage activation by ex vivo intervertebral discs using impedance cytometry.Biosensors & bioelectronics · 2022Article
- Deep neural network modeling identifies biomarkers of response to immune-checkpoint therapy.iScience · 2022Article
- Tumor necrosis factor-α-primed mesenchymal stem cell-derived exosomes promote M2 macrophage polarizationFrontiers in immunology · 2022Article
- Possible important roles of galectins in the healing of human fetal membranes.Frontiers in endocrinology · 2022Review
- Lipidome profiling with Raman microspectroscopy identifies macrophage response to surface topographies of implant materials.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Trichinella spiralis co-infection exacerbates Plasmodium berghei malaria-induced hepatopathy.Parasites & vectors · 2020Article
- Progress on Modulating Tumor-Associated Macrophages with Biomaterials.Advanced materials (Deerfield Beach, Fla.) · 2020Review
- Galectin-1 Facilitates Macrophage Reprogramming and Resolution of Inflammation Through IFN-β.Frontiers in pharmacology · 2020Article
- A Pro-resolving Role for Galectin-1 in Acute Inflammation.Frontiers in pharmacology · 2020Article
- Human galectin-1 and galectin-3 promoteGut microbesArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Regulating soft tissue repair to prevent fibrosis and promote regeneration is central to creating a microenvironment conducive to soft tissue development. Macrophages play an important role in this process. The macrophage response can be modulated using biomaterials, altering cytokine and growth factor secretion to promote regeneration. Electrospun polydioxanone (PDO) fiber scaffolds promoted an M2 phenotype when macrophages were cultured on large diameter, highly porous scaffolds, but an M1 phenotype on smaller diameter fibers. In this study, we investigated whether incorporation of galectin-1, an immunosuppressive protein that enhances muscle regeneration, could promote the M2 response. Galectin-1 was incorporated into large and small fiber PDO scaffolds during electrospinning. Galectin-1 incorporation increased arginase-1 and reduced iNOS and IL-6 production in mouse bone-marrow derived macrophages compared with PDO alone for both scaffold types. Inhibition of ERK mitogen-activated protein kinase did not alter galectin-1 effects on arginase-1 and iNOS expression, but reversed IL-6 suppression, indicating that IL-6 is mediated by a different mechanism. Our results suggest that galectin-1 can be used to modulate macrophage commitment to a pro-regenerative M2 phenotype, which may positively impact tissue regeneration when using small diameter PDO scaffolds. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 2562-2571, 2017.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.