ArticleHuman brain mapping2017
Genome-wide mediation analysis of psychiatric and cognitive traits through imaging phenotypes.
Article in Human brain mapping, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Genome-wide association study of cognitive function in diverse Hispanics/Latinos: results from the Hispanic Community Health Study/Study of Latinos.Translational psychiatry · 2020Pooled it
- S-GMAS: Genome-Wide Mediation Analysis With Brain Subcortical Shape Mediators.Human brain mapping · 2025Article
- MULTIVARIATE DYNAMIC MEDIATION ANALYSIS UNDER A REINFORCEMENT LEARNING FRAMEWORK.Annals of statistics · 2025Article
- Long-term effects of childhood single-parent family structure on brain connectivity and psychological well-being.Brain imaging and behavior · 2024Article
- The Influence of Structural Brain Changes on Cognition in the Context of Healthy Aging: Exploring Mediation Effects Through gBAT-The Graphical Brain Association Tool.Human brain mapping · 2024Article
- Mediation analysis in longitudinal study with high-dimensional methylation mediators.Briefings in bioinformatics · 2024Article
- AN INTEGRATIVE NETWORK-BASED MEDIATION MODEL (NMM) TO ESTIMATE MULTIPLE GENETIC EFFECTS ON OUTCOMES MEDIATED BY FUNCTIONAL CONNECTIVITY.The annals of applied statistics · 2024Article
- Imaging mediation analysis for longitudinal outcomes: a case study of childhood brain tumor survivorship.Statistics and its interface · 2024Article
- Mediation Analysis for High-Dimensional Mediators and Outcomes with an Application to Multimodal Imaging Data.Computational statistics & data analysis · 2023Article
- Bayesian nonparametric method for genetic dissection of brain activation region.Frontiers in neuroscience · 2023Article
- Mapping the Genetic-Imaging-Clinical Pathway with Applications to Alzheimer's Disease.Journal of the American Statistical Association · 2022Article
- Imaging Genetic Based Mediation Analysis for Human Cognition.Frontiers in neuroscience · 2022Article
- REVERSE phenotyping-Can the phenotype following constitutive Tph2 gene inactivation in mice be transferred to children and adolescents with and without adhd?Brain and behavior · 2021Article
- Mediation model with a categorical exposure and a censored mediator with application to a genetic study.PloS one · 2021Article
- Article
- Polygenic mediation analysis of Alzheimer's disease implicated intermediate amyloid imaging phenotypes.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2020Article
- Brain Imaging Genomics: Integrated Analysis and Machine Learning.Proceedings of the IEEE. Institute of Electrical and Electronics Engineers · 2020Article
- Genome-wide brain DNA methylation analysis suggests epigenetic reprogramming in Parkinson disease.Neurology. Genetics · 2019Article
- Genetic variants in SLC22A3 contribute to the susceptibility to colorectal cancer.International journal of cancer · 2019Article
- Spatial correlations exploitation based on nonlocal voxel-wise GWAS for biomarker detection of AD.NeuroImage. Clinical · 2019Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Heritability is well documented for psychiatric disorders and cognitive abilities which are, however, complex, involving both genetic and environmental factors. Hence, it remains challenging to discover which and how genetic variations contribute to such complex traits. In this article, they propose to use mediation analysis to bridge this gap, where neuroimaging phenotypes were utilized as intermediate variables. The Philadelphia Neurodevelopmental Cohort was investigated using genome-wide association studies (GWAS) and mediation analyses. Specifically, 951 participants were included with age ranging from 8 to 21 years. Two hundred and four neuroimaging measures were extracted from structural magnetic resonance imaging scans. GWAS were conducted for each measure to evaluate the SNP-based heritability. Furthermore, mediation analyses were employed to understand the mechanisms in which genetic variants have influence on pathological behaviors implicitly through neuroimaging phenotypes, and identified SNPs that would not be detected otherwise. Our analyses found that rs10494561, located in the intron region within NMNAT2, was associated with the severity of the prodromal symptoms of psychosis implicitly, mediated through the volume of the left hemisphere of the superior frontal region ( P=2.38×10-8). The gene NMNAT2 is known to be associated with brainstem degeneration, and produce cytoplasmic enzyme which is mainly expressed in the brain. Another SNP rs2285351 was found in the intron region of gene IFT122 which may be potentially associated with human spatial orientation ability through the area of the left hemisphere of the isthmuscingulate region ( P=3.70×10-8). Hum Brain Mapp 38:4088-4097, 2017. © 2017 Wiley Periodicals, Inc.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.