ArticleMolecular carcinogenesis2017
Interactions between calcium intake and polymorphisms in genes essential for calcium reabsorption and risk of colorectal neoplasia in a two-phase study.
Open access · greenAbstract read
In one paragraph
Article in Molecular carcinogenesis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Low dietary calcium intake leads to a higher colorectal cancer burden in countries with low social development: findings from the Global Burden of Disease Study 2021.Frontiers in nutrition · 2025Article
- The prognostic role of circulating tumour DNA detected prior to clinical diagnosis of colorectal cancer in the HUNT study.BMC cancer · 2024Observational
- Association of polymorphisms of calcium reabsorption genes SLC12A1, KCNJ1 and SLC8A1 with colorectal adenoma.Journal of cancer research and clinical oncology · 2023Article
- Exploration of spatial heterogeneity of tumor microenvironment in nasopharyngeal carcinoma via transcriptional digital spatial profiling.International journal of biological sciences · 2023Article
- Long-term use of antihypertensive medications, hypertension and colorectal cancer risk and mortality: a prospective cohort study.British journal of cancer · 2022Article
- Identification of key candidate genes and pathways in glioblastoma by integrated bioinformatical analysis.Experimental and therapeutic medicine · 2019Article
- The SLC transporter in nutrient and metabolic sensing, regulation, and drug development.Journal of molecular cell biology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 4 institutions in 2 countries.
Jing ZhaoDivision of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.
Xiangzhu ZhuDivision of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.
Martha J ShrubsoleDivision of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.
Reid M NessDepartment of Medicine, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee.
Elizabeth A HiblerDivision of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.
Qiuyin CaiDivision of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.
Jirong LongDivision of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.
Zhi ChenDivision of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.
Ming JiangDivision of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.
Edmond K KabagambeDivision of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.
Bing ZhangDivision of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.
Lifang HouDepartment of Preventive Medicine, Northwestern University, Chicago, Illinois.
Walter E SmalleyDepartment of Veterans Affairs, Tennessee Valley Healthcare System, Geriatric, Research, Education and Clinical Center (GRECC), Nashville, Tennessee.
Todd L EdwardsDivision of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.
Edward L GiovannucciDepartment of Nutrition and Epidemiology, Harvard School of Public Health, Boston, Massachusetts.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.
Qi DaiDivision of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.ORCID 0000-0003-1343-1494
Vanderbilt University · USMassachusetts Department of Public Health · USNantong University · CNNorthwestern University · US
Funding
Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STACIE B DUSETZINA · 1995 to 2026
$172.8MVANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7MUnderstanding and Controlling p120 Dysfunction in CRCP50CA095103 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI COFFEY, ROBERT J. · 2002 to 2017
$33.6MTranslational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9MTranslating gene-calcium interactions to precision medicine for colorectal cancerU01CA182364 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DAI, QI, EDWARDS, TODD L · 2014 to 2019
$2.9MGenetic and Endocrine Pathways Linking Obesity with Prostate CancerR01CA121060 · NCI · VANDERBILT UNIVERSITY · PI FOWKE, JAY H. · 2007 to 2011
$2.8MDietary Calcium and Magnesium, Genetics, and Colorectal AdenomaR01AT004660 · NCCIH · VANDERBILT UNIVERSITY · PI DAI, QI · 2008 to 2011
$2.1MPersonalized Prevention of Colorectal CancerR01CA149633 · NCI · VANDERBILT UNIVERSITY · PI DAI, QI, YU, CHANG · 2010 to 2014
$2.0MNCCIH NIH HHS R01 AT004660NCI NIH HHS P30 CA068485NCI NIH HHS P50 CA095103NCI NIH HHS R01 CA121060NCI NIH HHS R01 CA149633NCI NIH HHS U01 CA182364NCRR NIH HHS UL1 RR024975NIDDK NIH HHS P30 DK058404
Abstract
The SLC8A1 (solute carrier family 8, member 1) gene, encoding Na
Indexed as
AdultAgedCalbindin 1Calbindin 2Calcium, DietaryColorectal NeoplasmsFemaleHumansMaleMiddle AgedPharmacogenomic VariantsPlasma Membrane Calcium-Transporting ATPasesPolymorphism, Single NucleotideRisk FactorsSodium-Calcium ExchangerATP2B1 protein, humanCALB1 protein, humanCALB2 protein, humanCalbindin 1Calbindin 2Calcium, DietaryPlasma Membrane Calcium-Transporting ATPasesSodium-Calcium Exchangersodium-calcium exchanger 1colorectal neoplasiagene-calcium interactionKCNJ1SLC12A1SLC8A1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.