ArticleAngewandte Chemie (International ed. in English)2017
A Modular Flow Design for the meta-Selective C-H Arylation of Anilines.
Article in Angewandte Chemie (International ed. in English), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed.
- Automated Dynamic Flow Experimentation for Rapid Kinetic Fitting of Transition Metal Catalysis.Angewandte Chemie (International ed. in English) · 2026Article
- Review
- Acidity Controlled Formal Nucleophilic Substitution of Hydrofluoroolefin-Based Iodonium Salt with O-nucleophiles: Synthetic Application and Mechanistic Study.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Iodoarene Activation: Take a Leap Forward toward Green and Sustainable Transformations.Chemical reviews · 2025Review
- Synthesis of Hydrofluoroolefin-Based Iodonium Reagent via Dyotropic Rearrangement and Its Utilization in Fluoroalkylation.Angewandte Chemie (International ed. in English) · 2022Article
- Unraveling the mechanism for paired electrocatalysis of organics with water as a feedstock.Nature communications · 2022Article
- Stereoselective Direct N-Trifluoropropenylation of Heterocycles with a Hypervalent Iodonium Reagent.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Rh(i)- and Rh(ii)-catalyzed C-H alkylation of benzylamines with alkenes and its application in flow chemistry.Chemical science · 2021Article
- Visible-Light-Promoted Iron-Catalyzed C(spAngewandte Chemie (International ed. in English) · 2019Article
- H-bonded reusable template assisted para-selective ketonisation using soft electrophilic vinyl ethers.Nature communications · 2018Article
- One-pot synthesis of diaryliodonium salts from arenes and aryl iodides with Oxone-sulfuric acid.Beilstein journal of organic chemistry · 2018Article
- Flow Synthesis of Diaryliodonium Triflates.The Journal of organic chemistry · 2017Article
- A Modular Flow Design for the meta-Selective C-H Arylation of Anilines.Angewandte Chemie (International ed. in English) · 2017Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Described herein is an effective and practical modular flow design for the meta-selective C-H arylation of anilines. The design consists of four continuous-flow modules (i.e., diaryliodonium salt synthesis, meta-selective C-H arylation, inline copper extraction, and aniline deprotection) which can be operated either individually or consecutively to provide direct access to meta-arylated anilines. With a total residence time of 1 hour, the desired product could be obtained in high yield and excellent purity without the need for column chromatography, and the residual copper content meets the standards for parenterally administered pharmaceutical substances.
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