ArticleJournal of magnetic resonance imaging : JMRI2018
Cross-sectional correlation between hepatic R2* and proton density fat fraction (PDFF) in children with hepatic steatosis.
Article in Journal of magnetic resonance imaging : JMRI, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 24 citations in OpenAlex.
- Clinical assessment of hepatic steatosis and iron content using three-dimensional (3D) multi-echo chemical shift encoded magnetic resonance imaging (MRI): correlation with histopathology.Quantitative imaging in medicine and surgery · 2026Article
- Sex-specific associations in multiparametric 3 T MRI measurements in adult livers.Abdominal radiology (New York) · 2023Article
- Toward a realistic in silico abdominal phantom for QSM.Magnetic resonance in medicine · 2023Article
- Quantitative Susceptibility Mapping versus R2*-based Histogram Analysis for Evaluating Liver Fibrosis: Preliminary Results.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2022Article
- Hepatic Iron Quantification Using a Free-Breathing 3D Radial Gradient Echo Technique and Validation With a 2D Biopsy-Calibrated RJournal of magnetic resonance imaging : JMRI · 2022Article
- Spectroscopy-based multi-parametric quantification in subjects with liver iron overload at 1.5T and 3T.Magnetic resonance in medicine · 2022Article
- Quantitative MRI in cardiometabolic disease: From conventional cardiac and liver tissue mapping techniques to multi-parametric approaches.Frontiers in cardiovascular medicine · 2022Review
- Multiparametric MR mapping in clinical decision-making for diffuse liver disease.Abdominal radiology (New York) · 2020Review
- Liver fat accumulation measured by high-speed T2-corrected multi-echo magnetic resonance spectroscopy can predict risk of cholelithiasis.World journal of gastroenterology · 2020Article
- Normal range for MR elastography measured liver stiffness in children without liver disease.Journal of magnetic resonance imaging : JMRI · 2020Article
- Measurement of spleen fat on MRI-proton density fat fraction arises from reconstruction of noise.Abdominal radiology (New York) · 2019Article
- Hepatic R2* is more strongly associated with proton density fat fraction than histologic liver iron scores in patients with nonalcoholic fatty liver disease.Journal of magnetic resonance imaging : JMRI · 2019Article
- Sources of systematic error in proton density fat fraction (PDFF) quantification in the liver evaluated from magnitude images with different numbers of echoes.NMR in biomedicine · 2018Article
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Authors and funding
15 authors at 3 institutions in 1 country.
Funding
Abstract
purposeTo determine the relationship between hepatic proton density fat fraction (PDFF) and R2* in vivo. MATERIALS AND
methodsIn this Health Insurance Portability and Accountability Act (HIPAA)-compliant, Institutional Review Board (IRB)-approved, cross-sectional study, we conducted a secondary analysis of 3T magnetic resonance imaging (MRI) exams performed as part of prospective research studies in children in whom conditions associated with iron overload were excluded clinically. Each exam included low-flip-angle, multiecho magnitude (-M) and complex (-C) based chemical-shift-encoded MRI techniques with spectral modeling of fat to generate hepatic PDFF and R2* parametric maps. For each technique and each patient, regions of interest were placed on the maps in each of the nine Couinaud segments, and composite whole-liver PDFF and R2* values were calculated. Pearson's correlation coefficients between PDFF and R2* were computed for each MRI technique. Correlations were compared using Steiger's test.
resultsIn all, 184 children (123 boys, 61 girls) were included in this analysis. PDFF estimated by MRI-M and MRI-C ranged from 1.1-35.4% (9.44 ± 8.76) and 2.1-38.1% (10.1 ± 8.7), respectively. R2* estimated by MRI-M and MRI-C ranged from 32.6-78.7 s
conclusionHepatic PDFF and R2* are strongly correlated with each other in vivo. This relationship was observed using two different MRI techniques. LEVEL OF EVIDENCE: 2 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2018;47:418-424.
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