Evidence map›Paper›PMID 28543872›Full record

ArticleClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2017

PAI-1 gain-of-function genotype, factors increasing PAI-1 levels, and airway obstruction: The GALA II Cohort.

M G Sherenian, S H Cho, A Levin, J-Y Min, S S Oh, D Hu, J Galanter, S Sen, S Huntsman, C Eng and 10 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 8 institutions in 3 countries.

M G SherenianDivision of Allergy-Immunology, Department of Pediatrics, Northwestern University, Chicago, IL, USA.
S H ChoDivision of Allergy-Immunology, Department of Medicine, Northwestern University, Chicago, IL, USA.
A LevinDepartment of Public Health Science, Henry Ford Health System, Detroit, MI, USA.
J-Y MinDepartment of Otolaryngology, Northwestern University, Chicago, IL, USA.
S S OhDepartment of Medicine, University of California, San Francisco, CA, USA.
D HuDepartment of Medicine, University of California, San Francisco, CA, USA.
J GalanterDepartment of Medicine, University of California, San Francisco, CA, USA.
S SenDivision of Biostatistics, Department of Preventive Medicine, UTHSC, Memphis, TN, USA.
S HuntsmanDepartment of Medicine, University of California, San Francisco, CA, USA.
C EngDepartment of Medicine, University of California, San Francisco, CA, USA.
J R Rodriguez-SantanaCentro de Neumologia Pediatrica, CSP, San Juan, PR, USA.
D SerebriskyPediatric Pulmonary Division, Jacobi Medical Center, Bronx, NY, USA.
P C AvilaDivision of Allergy-Immunology, Department of Medicine, Northwestern University, Chicago, IL, USA.
R KalhanDivision of Pulmonary Medicine, Department of Medicine, Northwestern University, Chicago, IL, USA.
L J SmithDivision of Pulmonary Medicine, Department of Medicine, Northwestern University, Chicago, IL, USA.
L N BorrellDepartment of Health Sciences, Lehman College, CUNY, New York, NY, USA.
M A SeiboldCenter for Genes, Environment and Health, National Jewish Health, Denver, CO, USA.
L Keoki WilliamsDepartment of Internal Medicine, Henry Ford Health System, Detroit, MI, USA.
E G BurchardDepartment of Medicine, University of California, San Francisco, CA, USA.
R KumarDivision of Allergy-Immunology, Department of Pediatrics, Northwestern University, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-1962-7108
Northwestern University · USUniversity of California, San Francisco · USHenry Ford Health System · USCentro de Neumologia Pediatrica · PRJacobi Medical Center · USLehman College · USNational Jewish Health · USUniversity of Tennessee Health Science Center · US

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
Understanding Asthma EndotypesU19AI077439 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PRESCOTT G WOODRUFF · 2008 to 2026
$41.1M
New Approaches for Empowering Studies of Asthma in Populations of African DescentR01HL104608 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI BARNES, KATHLEEN C, KENNY, EIMEAR ELIZABETH · 2011 to 2022
$23.1M
Social Interventions to address disparities In young adult tobacco useP60MD006902 · NIMHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURCHARD, ESTEBAN GONZALEZ · 2012 to 2016
$6.4M
Gene-environments and Admixture in Latino Asthmatics (GALA 2)R01ES015794 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURCHARD, ESTEBAN GONZALEZ · 2008 to 2012
$5.4M
Postdoctoral training in tobacco controlR25CA113710 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GLANTZ, STANTON ARNOLD · 2006 to 2015
$5.4M
PHARMACOGENOMICS OF INHALED CORTICOSTEROID RESPONSIVENESS IN PATIENTS WITH ASTHMAR01AI079139 · NIAID · HENRY FORD HEALTH SYSTEM · PI WILLIAMS, KEOKI · 2009 to 2013
$3.9M
Whole Genome Analyses for Asthma in Latino PopulationsR01HL088133 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURCHARD, ESTEBAN GONZALEZ · 2008 to 2012
$3.8M
Combined Transcriptomics and Genomics to Find Asthma Genes in Admixed PopulationsR01HL118267 · NHLBI · HENRY FORD HEALTH SYSTEM · PI WILLIAMS, KEOKI · 2014 to 2017
$2.9M
Postdoctoral training in tobacco controlT32CA113710 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LING, PAMELA MAY · 2016 to 2020
$2.6M
Case-control Association Studies and Genetic ConfoundingR01HL078885 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURCHARD, ESTEBAN GONZALEZ · 2005 to 2009
$1.9M
Age related Differences in Chronic Rhinosinusitis and Nasal PolypsK23AI110731 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI CHO, SEONG HO · 2014 to 2018
$675k
American Heart Association-American Stroke Association 11SDG7590063NCATS NIH HHS UL1 TR001422NCI NIH HHS R25 CA113710NCI NIH HHS T32 CA113710NHLBI NIH HHS K23 HL093023NHLBI NIH HHS R01 HL078885NHLBI NIH HHS R01 HL088133NHLBI NIH HHS R01 HL104608NHLBI NIH HHS R01 HL118267NIAID NIH HHS K23 AI110731NIAID NIH HHS R01 AI079139NIAID NIH HHS U19 AI077439NIEHS NIH HHS R01 ES015794NIMHD NIH HHS L32 MD000659NIMHD NIH HHS P60 MD006902
6 · The paper itself

Abstract

backgroundPAI-1 gain-of-function variants promote airway fibrosis and are associated with asthma and with worse lung function in subjects with asthma.

objectiveWe sought to determine whether the association of a gain-of-function polymorphism in plasminogen activator inhibitor-1 (PAI-1) with airway obstruction is modified by asthma status, and whether any genotype effect persists after accounting for common exposures that increase PAI-1 level.

methodsWe studied 2070 Latino children (8-21y) with genotypic and pulmonary function data from the GALA II cohort. We estimated the relationship of the PAI-1 risk allele with FEV1/FVC by multivariate linear regression, stratified by asthma status. We examined the association of the polymorphism with asthma and airway obstruction within asthmatics via multivariate logistic regression. We replicated associations in the SAPPHIRE cohort of African Americans (n=1056). Secondary analysis included the effect of the at-risk polymorphism on postbronchodilator lung function.

resultsThere was an interaction between asthma status and the PAI-1 polymorphism on FEV CONCLUSIONS AND CLINICAL RELEVANCE: The decrease in the FEV

Indexed as

Gain of Function MutationAdolescentAdultAirway ObstructionAllelesAsthma, OccupationalChildCohort StudiesEthnicityFemaleGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeHumansMaleOdds RatioPlasminogen Activator Inhibitor 1SERPINE1 protein, humanasthmaepidemiologyPAI-1pediatrics

Identifiers

PMID28543872
PMCPMC5764093
OpenAlexW2619514783

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.