ArticleProtein science : a publication of the Protein Society2017
Experimental charge density from electron microscopic maps.
Article in Protein science : a publication of the Protein Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
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- Ligand identification in CryoEM and X-ray maps using deep learning.Bioinformatics (Oxford, England) · 2024Article
- Ligand Identification in CryoEM and X-ray Maps Using Deep Learning.bioRxiv : the preprint server for biology · 2024Article
- Direct measurements of biomolecular electrostatics through experiments.Current opinion in structural biology · 2023Review
- The Ycf48 accessory factor occupies the site of the oxygen-evolving manganese cluster during photosystem II biogenesis.Nature communications · 2023Article
- How to correct relative voxel scale factors for calculations of vector-difference Fourier maps in cryo-EM.Journal of structural biology · 2022Article
- Electron Diffraction of 3D Molecular Crystals.Chemical reviews · 2022Review
- Structural basis of Streptomyces transcription activation by zinc uptake regulator.Nucleic acids research · 2022Article
- Structural analyses of an RNA stability element interacting with poly(A).Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Opportunities and challenges for assigning cofactors in cryo-EM density maps of chlorophyll-containing proteins.Communications biology · 2020Review
- Structure of ribosome-bound azole-modified peptide phazolicin rationalizes its species-specific mode of bacterial translation inhibition.Nature communications · 2019Article
- CryoEM maps are full of potential.Current opinion in structural biology · 2019Review
- Challenges and opportunities in cryo-EM single-particle analysis.The Journal of biological chemistry · 2019Review
- On the damage done to the structure of the Thermoplasma acidophilum proteasome by electron radiation.Protein science : a publication of the Protein Society · 2018Article
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- Determination of chemical identity and occupancy from experimental density maps.Protein science : a publication of the Protein Society · 2018Article
- On the relationship between cumulative correlation coefficients and the quality of crystallographic data sets.Protein science : a publication of the Protein Society · 2017Article
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Abstract
The charge density (CD) distribution of an atom is the difference per unit volume between the positive charge of its nucleus and the distribution of the negative charges carried by the electrons that are associated with it. The CDs of the atoms in macromolecules are responsible for their electrostatic potential (ESP) distributions, which can now be visualized using cryo-electron microscopy at high resolution. CD maps can be recovered from experimental ESP density maps using the negative Laplacian operation. CD maps are easier to interpret than ESP maps because they are less sensitive to long-range electrostatic effects. An ESP-to-CD conversion involves multiplication of amplitudes of structure factors as Fourier transforms of these maps in reciprocal space by 1/d
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