Evidence map›Paper›PMID 28543853›Full record

ArticleProteins2017

Crystal structure of lipoate-bound lipoate ligase 1, LipL1, from Plasmodium falciparum.

Alfredo J Guerra, Gustavo A Afanador, Sean T Prigge

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proteins, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Alfredo J GuerraDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Gustavo A AfanadorDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Sean T PriggeDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.ORCID http://orcid.org/0000-0001-9684-1733
Johns Hopkins University · US

Funding

X-ray Absorption Spectroscopy (XAS) pp.711-759P41GM103393 · NIGMS · STANFORD UNIVERSITY · PI HODGSON, KEITH O · 2012 to 2019
$30.6M
Determinants of apicoplast maintenance in malaria parasitesR01AI125534 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Sean Taylor PRIGGE · 2016 to 2026
$3.9M
Roles of Lipoate Pathways in Plasmodium SurvivalR01AI065853 · NIAID · JOHNS HOPKINS UNIVERSITY · PI PRIGGE, SEAN TAYLOR · 2006 to 2010
$2.0M
Roles of lipoate pathways in Plasmodium survivalR56AI065853 · NIAID · JOHNS HOPKINS UNIVERSITY · PI PRIGGE, SEAN TAYLOR · 2012 to 2012
$400k
The POA-RpsA interaction in trans-translation inhibition in M. tuberculosisF32AI110028 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GUERRA, ALFREDO JOSE · 2014 to 2016
$157k
NIAID NIH HHS F32 AI110028NIAID NIH HHS R01 AI065853NIAID NIH HHS R01 AI125534NIAID NIH HHS R56 AI065853NIGMS NIH HHS P41 GM103393
6 · The paper itself

Abstract

Plasmodium falciparum lipoate protein ligase 1 (PfLipL1) is an ATP-dependent ligase that belongs to the biotin/lipoate A/B protein ligase family (PFAM PF03099). PfLipL1 is the only known canonical lipoate ligase in Pf and functions as a redox switch between two lipoylation routes in the parasite mitochondrion. Here, we report the crystal structure of a deletion construct of PfLipL1 (PfLipL1

Indexed as

Protein ConformationAdenosine TriphosphateAmino Acid SequenceCrystallography, X-RayPeptide SynthasesPlasmodium falciparumProtein BindingProtozoan ProteinsAdenosine Triphosphatelipoate-protein ligasePeptide SynthasesProtozoan ProteinsLipL1lipoatelipoate ligaselipoylationmalariaPlasmodium falciparum

Identifiers

PMID28543853
PMCPMC5568926
OpenAlexW2617655812

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.