Evidence map›Paper›PMID 28543407›Full record

Trial reportInternational journal of geriatric psychiatry2018

Assessing bipolar disorder in the older adult: the GERI-BD toolbox.

Patricia Marino, Herbert C Schulberg, Ariel G Gildengers, Benoit H Mulsant, Martha Sajatovic, Laszlo Gyulai, Rayan K Aljurdi, Laurie Davan Evans, Samprit Banerjee, Ruben C Gur and 2 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International journal of geriatric psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Patricia MarinoWeill Cornell Medical College, White Plains, NY, USA.ORCID http://orcid.org/0000-0002-5443-3229
Herbert C SchulbergWeill Cornell Medical College, White Plains, NY, USA.
Ariel G GildengersUniversity of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Benoit H MulsantUniversity of Toronto Faculty of Medicine, Toronto, Canada.
Martha SajatovicUH Case Medical Center, Cleveland, OH, USA.
Laszlo GyulaiUniversity of Pennsylvania, Philadelphia, PA, USA.
Rayan K AljurdiBaylor College of Medicine, Houston, TX, USA.
Laurie Davan EvansWeill Cornell Medical College, White Plains, NY, USA.
Samprit BanerjeeWeill Cornell Medical College, White Plains, NY, USA.
Ruben C GurUniversity of Pennsylvania, Philadelphia, PA, USA.
Robert C YoungWeill Cornell Medical College, White Plains, NY, USA.
GERI-BD Study Group

Funding

Cornell ACISR for Late Life DepressionP30MH068638 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI ALEXOPOULOS, GEORGE S · 2003 to 2007
$6.5M
The Effects of Bipolar Disorder and its Comorbidities on Cognition in Older AdultR01MH084921 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GILDENGERS, ARIEL GERARD · 2010 to 2014
$1.8M
Acute Pharmacotherapy of Late-Life Mania-Study Coordinating CenterU01MH074511 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI YOUNG, ROBERT C. · 2005 to 2009
$1.3M
Treatment of Bipolar Disorder in Old AgeK02MH067028 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI YOUNG, ROBERT C. · 2003 to 2013
$1.2M
Acute Pharmacotherapy of Late-Life ManiaU01MH068847 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI YOUNG, ROBERT C. · 2005 to 2009
$650k
NIMH NIH HHS K02 MH067028NIMH NIH HHS P30 MH068638NIMH NIH HHS R01 MH084921NIMH NIH HHS U01 MH068847NIMH NIH HHS U01 MH074511
6 · The paper itself

Abstract

introductionThe evidence base regarding characteristics of older adults with bipolar disorder (BD) remains limited. The NIH-funded multicenter study Acute Pharmacotherapy of Late-Life Mania (GERI-BD) assessed various clinical domains before and during mood stabilizer treatment in older adults participating in a 9-week, double-blind randomized controlled trial. We describe the rationale for selecting these instruments.

methodsDomains and instruments were selected on the basis of the study design and the participants. The investigators' experience in clinical trials involving young adults with BD or older adults with major depressive disorder, along with open studies of older adults with BD, contributed to the selection process.

resultsWe identified domains and selected instruments that could be used to assess the participants given their diagnostic, treatment history, and medical and mood state characteristics. They were also intended to measure tolerability and efficacy and permit examination of potential moderating and mediating factors.

conclusionsDecisions regarding the assessment domains to be included in the clinical trial highlight the challenges facing researchers studying drug treatments for older adults with BD, or more generally, mood disorders. We suggest that the domains and instruments selected by GERI-BD investigators constitute a "toolbox" that can be customized for other investigators. Copyright © 2017 John Wiley & Sons, Ltd.

Indexed as

AgedAntimanic AgentsBipolar DisorderDouble-Blind MethodDrug Therapy, CombinationFemaleGeriatric AssessmentHumansLithiumMajor Depressive DisorderMaleMiddle AgedMood DisordersValproic AcidAntimanic AgentsLithiumValproic Acidassessmentbipolar disordermaniaolder adult

Identifiers

PMID28543407
PMCPMC6093209

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.