Evidence map›Paper›PMID 28543165›Full record

Observational studyAmerican journal of hematology2017

Recognition of early mortality in multiple myeloma by a prediction matrix.

Howard Terebelo, Shankar Srinivasan, Mohit Narang, Rafat Abonour, Cristina Gasparetto, Kathleen Toomey, James W Hardin, Gail Larkins, Amani Kitali, Robert M Rifkin and 1 more

Registry-linked trialAbstract readMulticenter StudyObservational Study
In one paragraph

Observational study in American journal of hematology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01081028 (Connect® MM- The Multiple Myeloma Disease Registry), which is not on this map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01081028 terminatednot on this map

Connect® MM- The Multiple Myeloma Disease Registry

Typeobservational_patient_registrySponsorCelgeneRan2009 to 2024Enrolled3,011ConditionsMultiple MyelomaArmsFirst-line therapy, Second-line Multiple Myeloma treatments
3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Advanced disease and CD8Frontiers in immunology · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Eastern Cooperative Oncology Group,Frontiers in microbiology · 2023
    Article
  12. Article
  13. IntestinalCancers · 2022
    Article
  14. Establishment and Validation for Predicting the Death of Multiple Myeloma among Whites.Evidence-based complementary and alternative medicine : eCAM · 2022
    Article
  15. Article
  16. Article
  17. Article
  18. Observational
  19. Observational
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Howard TerebeloProvidence Cancer Center, Southfield, Michigan.ORCID http://orcid.org/0000-0002-4208-2353
Shankar SrinivasanCelgene Corporation, Summit, New Jersey.
Mohit NarangMaryland Oncology Hematology, Columbia, Maryland.
Rafat AbonourIndiana University Simon Cancer Center, Indianapolis, Indiana.
Cristina GasparettoDivision of Cellular Therapy, Duke University Medical Center, Durham, North Carolina.
Kathleen ToomeySteeplechase Cancer Center, Somerville, New Jersey.
James W HardinUniversity of South Carolina, Columbia, South Carolina.
Gail LarkinsCelgene Corporation, Summit, New Jersey.
Amani KitaliCelgene Corporation, Summit, New Jersey.
Robert M RifkinUS Oncology Research, Rocky Mountain Cancer Centers, Denver, Colorado.
Jatin J ShahThe University of Texas MD Anderson Cancer Center, Houston, Texas.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early mortality (EM; death ≤ 6 months from diagnosis) has been reported in several newly diagnosed multiple myeloma (NDMM) trials. Before the era of novel agents, the incidence was 10%-14%. Causes of death included infections/pneumonia, renal failure, refractory disease, and cardiac events. Staging systems, such as the revised International Staging System (r-ISS), and prognostic factors including cytogenetics, lactate dehydrogenase levels, and myeloma-specific factors, are useful to assess overall prognosis; however, they cannot predict EM. We evaluated patients treated with novel agents in the Connect MM

Indexed as

Multiple MyelomaRegistriesAdultAgedAged, 80 and overBiomarkers, TumorDisease-Free SurvivalFemaleFollow-Up StudiesHumansHypertensionInfectionsL-Lactate DehydrogenaseMaleMiddle AgedPlatelet CountBiomarkers, TumorL-Lactate Dehydrogenase

Identifiers

PMID28543165
PMCPMC5601204

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.