ArticleBritish journal of pharmacology2017
The inward rectifier current inhibitor PA-6 terminates atrial fibrillation and does not cause ventricular arrhythmias in goat and dog models.
Article in British journal of pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Interplay between variability in intrinsic cellular properties and heart failure-associated remodeling in a simulated population with human heart failure.Journal of molecular and cellular cardiology · 2026Article
- Animal and cellular models of atrial fibrillation: a review.Frontiers in cardiovascular medicine · 2025Review
- The network of cardiac KNaunyn-Schmiedeberg's archives of pharmacology · 2024Review
- Article
- Analysis of drug-induced and spontaneous cardioversions reveals similar patterns leading to termination of atrial fibrillation.Frontiers in physiology · 2024Article
- Kir2.1-mediated membrane potential promotes nutrient acquisition and inflammation through regulation of nutrient transporters.Nature communications · 2022Article
- The canine chronic atrioventricular block model in cardiovascular preclinical drug research.British journal of pharmacology · 2022Review
- Article
- Molecular Insights in Atrial Fibrillation Pathogenesis and Therapeutics: A Narrative Review.Diagnostics (Basel, Switzerland) · 2021Review
- Investigational Anti-Atrial Fibrillation Pharmacology and Mechanisms by Which Antiarrhythmics Terminate the Arrhythmia: Where Are We in 2020?Journal of cardiovascular pharmacology · 2020Review
- Towards the Development of AgoKirs: New Pharmacological Activators to Study KInternational journal of molecular sciences · 2020Review
- The Acetylcholine-Activated Potassium Current Inhibitor XAF-1407 Terminates Persistent Atrial Fibrillation in Goats.Frontiers in pharmacology · 2020Article
- Mechanisms by Which Ranolazine Terminates Paroxysmal but Not Persistent Atrial Fibrillation.Circulation. Arrhythmia and electrophysiology · 2019Article
- Computational modeling: What does it tell us about atrial fibrillation therapy?International journal of cardiology · 2019Review
- The Increment of Short-term Variability of Repolarisation Determines the Severity of the Imminent Arrhythmic Outcome.Arrhythmia & electrophysiology review · 2019Review
- Differential Modulation ofFrontiers in physiology · 2019Article
- Efficacy of pentamidine analogue 6 in dogs with chronic atrial fibrillation.Journal of veterinary internal medicine · 2018Article
- The inward rectifier current inhibitor PA-6 terminates atrial fibrillation and does not cause ventricular arrhythmias in goat and dog models.British journal of pharmacology · 2017Article
- PA-6 inhibits inward rectifier currents carried by V93I and D172N gain-of-function KJournal of biomedical science · 2017Article
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 3 countries.
Funding
Abstract
background and purposeThe density of the inward rectifier current (I EXPERIMENTAL APPROACH: PA-6 was applied i.v. in anaesthetized goats with rapid pacing-induced AF and anaesthetized dogs with chronic atrio-ventricular (AV) block. Electrophysiological and pharmacological parameters were determined. KEY
resultsPA-6 (2.5 mg·kg CONCLUSION AND IMPLICATIONS: PA-6 restored SR in goats with persistent AF and, in dogs with chronic AV block, prolonged QT intervals, without inducing TdP arrhythmias. Our results demonstrate cardiac safety and good anti-AF properties for PA-6.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.