ArticlePLoS pathogens2017
Highly efficient maternal-fetal Zika virus transmission in pregnant rhesus macaques.
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Article in PLoS pathogens, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 143 papers.
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143citing papers in PubMed
34.2field-weighted citation impact, top 1% of its field
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Who cites it
143 citing papers in PubMed, 224 citations in OpenAlex.
- A framework for assessing potential Oropouche virus-associated adverse fetal outcomes.BMC infectious diseases · 2026Article
- Targeted nanoparticles for placenta-specific drug delivery in pregnant rhesus macaques.Theranostics · 2026Article
- Neutrophils at the Maternal-Fetal Interface: Agents of Protection or Destruction?American journal of reproductive immunology (New York, N.Y. : 1989) · 2025Review
- Variation in virion phosphatidylserine content drives differential GAS6 binding among closely related flaviviruses.Journal of virology · 2025Article
- Nanoparticle-mediated delivery of placental gene therapy via uterine artery catheterization in a pregnant rhesus macaque.Placenta · 2025Article
- Role of non-human primate models in accelerating research and developing countermeasures against Zika virus infection.The Lancet. Microbe · 2025Review
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- Pathological characterization of female reproductive organs prior to miscarriage induced by Zika virus infection in the pregnant common marmoset.Microbiology spectrum · 2025Article
- An Overview of Zika Virus and Zika Virus Induced Neuropathies.International journal of molecular sciences · 2024Review
- The Laboratory Opossum (Viruses · 2024Article
- Placental gene therapy in nonhuman primates: a pilot study of maternal, placental, and fetal response to non-viral, polymeric nanoparticle delivery of IGF1.Molecular human reproduction · 2024Article
- Comprehensive Overview of Methods of Pregnancy Termination in Macaques and Marmosets.Veterinary sciences · 2024Review
- Fetal Zika virus inoculation in macaques revealed control of the fetal viral load during pregnancy.Virology journal · 2024Article
- Ad26.M.Env ZIKV vaccine protects pregnant rhesus macaques and fetuses against Zika virus infection.NPJ vaccines · 2024Article
- Disruption of myelin structure and oligodendrocyte maturation in a macaque model of congenital Zika infection.Nature communications · 2024Article
- Article
- Postnatal Zika virus infection leads to morphological and cellular alterations within the neurogenic niche.Disease models & mechanisms · 2024Article
- Decidual leukocytes respond to African lineage Zika virus infection with mild anti-inflammatory changes during acute infection in rhesus macaques.Frontiers in immunology · 2024Article
- Vertical transmission of African-lineage Zika virus through the fetal membranes in a rhesus macaque (Macaca mulatta) model.PLoS pathogens · 2023Article
- Zika virus infection histories in brain development.Disease models & mechanisms · 2023Review
83 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
39 authors at 3 institutions in 1 country.
Sydney M NguyenDepartment of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.ORCID http://orcid.org/0000-0002-1354-7078
Kathleen M AntonyDepartment of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.ORCID http://orcid.org/0000-0003-3537-8030
Dawn M DudleyDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Sarah KohnDepartment of Radiology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.ORCID http://orcid.org/0000-0002-2213-9332
Heather A SimmonsWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Bryce WolfeDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.ORCID http://orcid.org/0000-0003-0418-8816
M Shahriar SalamatDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Leandro B C TeixeiraSchool of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.ORCID http://orcid.org/0000-0001-9960-678X
Gregory J WiepzDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.ORCID http://orcid.org/0000-0002-8453-7256
Troy H ThoongWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Matthew T AliotaDepartment of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.ORCID http://orcid.org/0000-0002-6902-9149
Andrea M WeilerWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Gabrielle L BarryWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Kim L WeisgrauWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Logan J VoslerWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Mariel S MohnsDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Meghan E BreitbachDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Laurel M StewartDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Mustafa N RasheedDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.ORCID http://orcid.org/0000-0002-4037-5486
Christina M NewmanDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Michael E GrahamDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Oliver E WiebenDepartment of Radiology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.ORCID http://orcid.org/0000-0002-7931-1930
Patrick A TurskiDepartment of Radiology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Kevin M JohnsonDepartment of Radiology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.ORCID http://orcid.org/0000-0002-8660-0853
Jennifer PostWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Jennifer M HayesWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Nancy Schultz-DarkenWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.ORCID http://orcid.org/0000-0002-8436-2820
Michele L SchotzkoWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Josh A EudaileyDepartment of Pediatrics and Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, United States of America.ORCID http://orcid.org/0000-0002-1731-9806
Sallie R PermarDepartment of Pediatrics and Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, United States of America.
Eva G RakaszWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Emma L MohrDepartment of Pediatrics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.ORCID http://orcid.org/0000-0003-0742-305X
Saverio CapuanoWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Alice F TarantalDepartments of Pediatrics and Cell Biology and Human Anatomy, University of California-Davis, California National Primate Research Center, Davis, California, United States of America.
Jorge E OsorioDepartment of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Shelby L O'ConnorDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Thomas C FriedrichWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.ORCID http://orcid.org/0000-0001-9831-6895
David H O'ConnorDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.ORCID http://orcid.org/0000-0003-2139-470X
Thaddeus G GolosDepartment of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.ORCID http://orcid.org/0000-0002-7897-4337
University of Wisconsin–Madison · USDuke Medical Center · USUniversity of California, Davis · US
Funding
National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5MWNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7MGBV-C-mediated protection from AIDS in humans and GBV-C/SIV co-infected macaquesR01AI116382 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI O'CONNOR, DAVID H. · 2015 to 2018
$6.5MAdvanced MRI FOR Uteroplacental Flow, Perfusion, Oxygenation & InflammationU01HD087216 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI SHAH, DINESH MANILAL, WIEBEN, OLIVER · 2015 to 2015
$4.0MEXTRAMURAL RES FACIL CONST: REPRODUCTIVE, GROWTH &DVMT, MENOPAUSEC06RR020141 · NCRR · UNIVERSITY OF WISCONSIN MADISON · PI CADWALLADER, MARTIN · 2004 to 2004
$3.6MMaternal immune protection against congenital CMV infectionDP2HD075699 · NICHD · DUKE UNIVERSITY · PI PERMAR, SALLIE R. · 2012 to 2017
$2.8MEXTRAMURAL REGIONAL FACILITIES CONSTRUCTIONC06RR015459 · NCRR · UNIVERSITY OF WISCONSIN MADISON · PI CADWALLADER, MARTIN · 2000 to 2000
$1.9MThe Maternal-Fetal Interface in Listeria-Induced Pregnancy LossR01AI107157 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI GOLOS, THADDEUS G · 2014 to 2017
$1.6MNCRR NIH HHS C06 RR015459NCRR NIH HHS C06 RR020141NIAID NIH HHS R01 AI107157NIAID NIH HHS R01 AI116382NICHD NIH HHS DP2 HD075699NICHD NIH HHS U01 HD087216NIH HHS P51 OD011106NIH HHS P51 OD011107
Abstract
Infection with Zika virus (ZIKV) is associated with human congenital fetal anomalies. To model fetal outcomes in nonhuman primates, we administered Asian-lineage ZIKV subcutaneously to four pregnant rhesus macaques. While non-pregnant animals in a previous study contemporary with the current report clear viremia within 10-12 days, maternal viremia was prolonged in 3 of 4 pregnancies. Fetal head growth velocity in the last month of gestation determined by ultrasound assessment of head circumference was decreased in comparison with biparietal diameter and femur length within each fetus, both within normal range. ZIKV RNA was detected in tissues from all four fetuses at term cesarean section. In all pregnancies, neutrophilic infiltration was present at the maternal-fetal interface (decidua, placenta, fetal membranes), in various fetal tissues, and in fetal retina, choroid, and optic nerve (first trimester infection only). Consistent vertical transmission in this primate model may provide a platform to assess risk factors and test therapeutic interventions for interruption of fetal infection. The results may also suggest that maternal-fetal ZIKV transmission in human pregnancy may be more frequent than currently appreciated.
Indexed as
Infectious Disease Transmission, VerticalPregnancy Complications, InfectiousAmniotic FluidAnimalsDeciduaDisease Models, AnimalFemaleFetal DevelopmentFetusHumansLungMacaca mulattaPlacentaPregnancyRNA, ViralSpleenRNA, Viral
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