ArticlePloS one2017
Ultrasonography methods for predicting malignancy in canine mammary tumors.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Quantitative Parameters of Contrast-Enhanced Ultrasonography (CEUS) Monitoring Ovarian Hemodynamics in Rats.Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association · 2026Article
- Preoperative Clinical Predictors of Histologic Malignancy and Carcinoma Grade in 286 Canine Mammary Nodules from 92 Bitches: A Retrospective Study.Animals : an open access journal from MDPI · 2026Article
- Diagnostic Imaging Features of Mammary Gland Tumors in Dogs and Cats.Animals : an open access journal from MDPI · 2025Review
- B-Mode Ultrasonography and Acoustic Radiation Force Impulse Elastography in Evaluation of Urothelial Carcinoma in Dogs.Animals : an open access journal from MDPI · 2025Article
- Shear Wave Elastography Evaluation of Testicular Stiffness in Dogs Affected by Testicular Pathology.Animals : an open access journal from MDPI · 2025Article
- Use of New Ultrasonography Methods for Detecting Neoplasms in Dogs and Cats: A Review.Animals : an open access journal from MDPI · 2024Review
- Evaluation of ARFI elastography for detecting active mastitis in sheep with previous fibrous lesions: a study of mammary parenchyma and supramammary lymph nodes.Animal reproduction · 2024Article
- B-mode ultrasonography and ARFI elastography of articular and peri-articular structures of the hip joint in non-dysplastic and dysplastic dogs as confirmed by radiographic examination.BMC veterinary research · 2023Article
- The Importance of Ultrasonography in the Evaluation of Mammary Tumors in Bitches.Animals : an open access journal from MDPI · 2023Review
- Contrast-Enhanced Ultrasonography (CEUS) in Imaging of the Reproductive System in Dogs: A Literature Review.Animals : an open access journal from MDPI · 2023Review
- Modern Imaging Techniques in the Study and Disease Diagnosis of the Mammary Glands of Animals.Veterinary sciences · 2023Review
- The Analysis of E-Cadherin, N-Cadherin, Vimentin, HER-2, CEA, CA15-3 and SF Expression in the Diagnosis of Canine Mammary Tumors.Animals : an open access journal from MDPI · 2022Article
- B-Mode and Contrast-Enhanced Ultrasonography Aspects of Benign and Malignant Superficial Neoplasms in Dogs: A Preliminary Study.Animals : an open access journal from MDPI · 2022Article
- The Novel Diagnostic Techniques and Biomarkers of Canine Mammary Tumors.Veterinary sciences · 2022Review
- Strain and Shear-Wave Elastography and Their Relationship to Histopathological Features of Canine Mammary Nodular Lesions.Veterinary sciences · 2022Article
- Accuracy of B-mode ultrasound and ARFI elastography in predicting malignancy of canine splenic lesions.Scientific reports · 2022Article
- Malignancy prediction of cutaneous and subcutaneous neoplasms in canines using B-mode ultrasonography, Doppler, and ARFI elastography.BMC veterinary research · 2022Article
- Comparison between Histological Features and Strain Elastographic Characteristics in Canine Mammary Carcinomas.Veterinary sciences · 2021Article
- Decreased Size of Mammary Tumors Caused by Preoperative Treatment with Aglepristone in Female Domestic Dogs (Animals : an open access journal from MDPI · 2021Article
- Ultrasonographic Algorithm for the Assessment of Sentinel Lymph Nodes That Drain the Mammary Carcinomas in Female Dogs.Animals : an open access journal from MDPI · 2020Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to evaluate and compare the efficacy of B-mode, Doppler, contrast-enhanced ultrasonography (CEUS), and Acoustic Radiation Force Impulse (ARFI) elastography in predicting malignancy in canine mammary masses. This was a prospective cohort study from 2014 to 2016, which included 153 bitches with one or more mammary masses. A total of 300 masses were evaluated by ultrasonography (B-mode, Doppler, CEUS, and ARFI) and subsequently classified as benign or malignant by histopathology. Each ultrasound parameters studied were compared between benign and malignant masses by Chi-square or Student tests and differences were considered significant when P < 0.01. For the variables that proved significant differences were estimated the cut-off point, sensitivity, specificity, accuracy, and area under curve (AUC) by receiver-operating characteristic curve (ROC) analysis in a logistic regression model using histopathological classification as reference, to assess and compare diagnostic performance of each technique. Out of 300 mammary masses evaluated 246 were classified as malignant and 54 as benign. B-mode measurements showed sensitivity 67.9%, and specificity 67.6% as malignancy predictors on canine mammary masses; Doppler indexes systolic (>21.2 m/s) and diastolic velocity (>4.8 m/s) sensitivity 79.2% and specificity 70.8%; CEUS wash-out time (<80.5 s) sensitivity 80.2% and specificity 16.7%; and ARFI elastography shear velocity (SWV > 2.57 m/s) sensitivity 94.7% and specificity 97.2% In conclusion B-mode and Doppler ultrasound evaluations may assist in malignancy prediction of canine mammary masses with moderate sensitivity and specificity, already the SWV was an great accurate predictor. Therefore, ARFI elastography exam inclusion in veterinary clinic oncology and research is highly recommended, since it allows fast, non-invasive, and complication-free malignancy prediction of canine mammary masses.
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