ArticlePloS one2017
Regeneration of myelin sheaths of normal length and thickness in the zebrafish CNS correlates with growth of axons in caliber.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- Review
- Myelin sheaths in the central nervous system can withstand damage and dynamically remodel.Science (New York, N.Y.) · 2026Article
- P/Q-type voltage-gated calcium channels regulate calcium signaling and developmental myelination in oligodendrocyte lineage cells.bioRxiv : the preprint server for biology · 2025Article
- Activation of cannabinoid receptor CB1 leads to aberrant myelination in development.bioRxiv : the preprint server for biology · 2025Article
- Oligodendrocytes support functional development of subcortical premotor neurons and navigation.bioRxiv : the preprint server for biology · 2025Article
- FBXW7 regulates MYRF levels to control myelin capacity and homeostasis in the adult central nervous system.Nature communications · 2025Article
- A focus on the normal-appearing white and gray matter within the multiple sclerosis brain: a link to smoldering progression.Acta neuropathologica · 2025Review
- Radiologic Lag and Brain MRI Lesion Dynamics During Attacks in MOG Antibody-Associated Disease.Neurology · 2024Observational
- Oligodendrocyte precursor cells sculpt the visual system by regulating axonal remodeling.Nature neuroscience · 2022Article
- The Larval Zebrafish Vestibular System Is a Promising Model to Understand the Role of Myelin in Neural Circuits.Frontiers in neuroscience · 2022Article
- CNS Hypomyelination Disrupts Axonal Conduction and Behavior in Larval Zebrafish.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- In vivo imaging reveals mature Oligodendrocyte division in adult Zebrafish.Cell regeneration (London, England) · 2021Article
- Building a (w)rapport between neurons and oligodendroglia: Reciprocal interactions underlying adaptive myelination.Neuron · 2021Review
- Insights Into Central Nervous System Glial Cell Formation and Function From Zebrafish.Frontiers in cell and developmental biology · 2021Review
- Proteome Profile of Myelin in the Zebrafish Brain.Frontiers in cell and developmental biology · 2021Article
- A Novel Lysolecithin Model for Visualizing DamageFrontiers in cell and developmental biology · 2021Article
- Pro-inflammatory activation following demyelination is required for myelin clearance and oligodendrogenesis.The Journal of experimental medicine · 2020Article
- Functionally distinct subgroups of oligodendrocyte precursor cells integrate neural activity and execute myelin formation.Nature neuroscience · 2020Article
- Experimental Models of Neuroimmunological Disorders: A Review.Frontiers in neurology · 2020Review
- Characterization of myelin oligodendrocyte glycoprotein (MOG)35-55-specific CD8+ T cells in experimental autoimmune encephalomyelitis.Chinese medical journal · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
Demyelination is observed in numerous diseases of the central nervous system, including multiple sclerosis (MS). However, the endogenous regenerative process of remyelination can replace myelin lost in disease, and in various animal models. Unfortunately, the process of remyelination often fails, particularly with ageing. Even when remyelination occurs, it is characterised by the regeneration of myelin sheaths that are abnormally thin and short. This imperfect remyelination is likely to have implications for the restoration of normal circuit function and possibly the optimal metabolic support of axons. Here we describe a larval zebrafish model of demyelination and remyelination. We employ a drug-inducible cell ablation system with which we can consistently ablate 2/3rds of oligodendrocytes in the larval zebrafish spinal cord. This leads to a concomitant demyelination of 2/3rds of axons in the spinal cord, and an innate immune response over the same time period. We find restoration of the normal number of oligodendrocytes and robust remyelination approximately two weeks after induction of cell ablation, whereby myelinated axon number is restored to control levels. Remarkably, we find that myelin sheaths of normal length and thickness are regenerated during this time. Interestingly, we find that axons grow significantly in caliber during this period of remyelination. This suggests the possibility that the active growth of axons may stimulate the regeneration of myelin sheaths of normal dimensions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.