ArticlePloS one2017
Maternal low thyroxin levels are associated with adverse pregnancy outcomes in a Chinese population.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Periconceptional biomarkers for maternal obesity: a systematic review.Reviews in endocrine & metabolic disorders · 2023Pooled it
- Association of thyroid disorders with gestational diabetes mellitus: a meta-analysis.Endocrine · 2021Pooled it
- The Need for Dynamic Clinical Guidelines: A Systematic Review of New Research Published After Release of the 2017 ATA Guidelines on Thyroid Disease During Pregnancy and the Postpartum.Frontiers in endocrinology · 2020Pooled it
- Effect of Levothyroxine on Pregnancy Outcomes in Pregnant Women With Hypothyroxinemia: An Interventional Study.Frontiers in endocrinology · 2022Trial
- Trial
- Asymmetric U-shaped association between first-trimester maternal free thyroxine levels and the risk of preeclampsia: a large-scale cohort study.Journal of hypertension · 2026Article
- The Adverse Effects of Anxiety and Depression on Pregnant Women with Hypothyroidism in Late Pregnancy.Actas espanolas de psiquiatria · 2024Article
- Defining Trimester-Specific Reference Intervals for Thyroid Hormones: Insights from a Bulgarian Monocenter Study.Medicina (Kaunas, Lithuania) · 2024Article
- The Association between Maternal Urinary Phthalate Concentrations and Blood Pressure in Pregnancy: A Systematic Review and Meta-Analysis.Metabolites · 2023Review
- Higher Thyroid fT3-to-fT4 Ratio Is Associated with Gestational Diabetes Mellitus and Adverse Pregnancy Outcomes.Journal of clinical medicine · 2022Article
- Analytical Comparison of Risk Prediction Models for the Onset of Macrosomia Based on Three Statistical Methods.Disease markers · 2022Article
- Associations of Hypothyroxinemia With Risk of Preeclampsia-Eclampsia and Gestational Hypertension.Frontiers in endocrinology · 2021Article
- Unique Biomarker Characteristics in Gestational Diabetes Mellitus Identified by LC-MS-Based Metabolic Profiling.Journal of diabetes research · 2021Article
- Phthalates Implications in the Cardiovascular System.Journal of cardiovascular development and disease · 2020Review
- Association between thyroid dysfunction and perinatal outcomes in women with gestational hypertension: a retrospective study.BMC pregnancy and childbirth · 2020Article
- Molecular Modelling of Islet β-Cell Adaptation to Inflammation in Pregnancy and Gestational Diabetes Mellitus.International journal of molecular sciences · 2019Review
- Maternal use of drugs and preeclampsia.British journal of clinical pharmacology · 2019Article
- Thyroid Dysfunction and Diabetes Mellitus: Two Closely Associated Disorders.Endocrine reviews · 2019Review
- Association between isolated hypothyroxinaemia in early pregnancy and perinatal outcomes.Endocrine connections · 2019Article
- Reference Intervals of Thyroid Hormones and Correlation of BMI with Thyroid Function in Healthy Zhuang Ethnic Pregnant Women.BioMed research international · 2018Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although thyroid dysfunction in early pregnancy may have adverse effects on pregnancy outcomes, few studies have examined the relationship between maternal low free thyroxin (FT4) levels in both first and third trimesters of pregnancy and the incidence of adverse pregnancy outcomes. We hypothesized that low FT4 levels in either first or third trimesters of pregnancy may have different effects on pregnancy outcomes. The study included 6,031 mothers who provided both first and third pregnancy serum samples for analyses of thyroid function. Adverse pregnancy outcomes, such as gestational diabetes mellitus (GDM), pregnancy-induced hypertension and preeclampsia, were diagnosed using the oral glucose tolerance test, blood pressure and urine protein test. Serum metabolites like adenosine and its analogues were identified using hydrophilic interaction liquid chromatography (HILIC)-tandem mass spectrometry (MS/MS). The incidence of hypothyroidism in pregnant women tended to increase with age and pre-pregnancy body mass index (BMI). The incidence of GDM was negatively correlated with maternal FT4 levels during early pregnancy while the incidence of preeclampsia was negatively correlated with maternal FT4 levels during late pregnancy. The incidence of pregnancy-induced hypertension was not significantly correlated with maternal FT4 levels. The women who had isolated maternal hypothyroxemia (IMH) in the third trimester of pregnancy had an increased risk of developing preeclampsia. Some metabolites like adenosine and its analogues in the serum were significantly changed in pregnant mothers with IMH. In conclusion, low FT4 levels during pregnancy are a risk factor for GDM and preeclampsia. Adenosine and its analogues may be important bridges between IMH and preeclampsia.
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