ArticlePloS one2017
Angelica Dahurica ethanolic extract improves impaired wound healing by activating angiogenesis in diabetes.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- The potential application of natural products in cutaneous wound healing: A review of preclinical evidence.Frontiers in pharmacology · 2022Pooled it
- The Bath Additive KTPB Induces an Angiogenesis-Associated Transcriptional Program Without Detectable Cytotoxicity in Human Vascular Endothelial Cells.Current issues in molecular biology · 2026Article
- Menthol-Based Cream as a Novel Therapy for Diabetic Skin Wounds.Pharmaceutics · 2026Article
- Medicinal Plants Facilitate the Recovery of Diabetic Foot Ulcer by Regulating Macrophages: Latest Evidence and Insights.Current diabetes reviews · 2026Review
- Mechanistic Insights into the Wound Healing Activity of Plant Species in Diabetic Ulcers.Current issues in molecular biology · 2025Review
- Advances in traditional Chinese medicine for burn treatment: mechanisms, therapeutic approaches, and innovative preparations.Frontiers in pharmacology · 2025Review
- Advanced Natural Therapeutics and Delivery Strategies for Diabetic Foot Ulcers: A Mini Review.Drug design, development and therapy · 2025Review
- Zuyangping formula promotes skin wound healing in diabetic rats.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2024Article
- Kampo herbal ointments for skin wound healing.Frontiers in pharmacology · 2023Review
- Preclinical Trial ofEvidence-based complementary and alternative medicine : eCAM · 2023Article
- Therapeutic Effect and Mechanism of Negative Pressure Wound Therapy with Huoxue Shengji Decoction Instillation for Chronic Skin Ulcers.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Botanical Drugs in Traditional Chinese Medicine With Wound Healing Properties.Frontiers in pharmacology · 2022Review
- "Q-markers targeted screening" strategy for comprehensive qualitative and quantitative analysis in fingerprints ofFood chemistry: X · 2021Article
- A Phenylfurocoumarin Derivative Reverses ABCG2-Mediated Multidrug Resistance In Vitro and In Vivo.International journal of molecular sciences · 2021Article
- Construction of multifunctional porcine acellular dermal matrix hydrogel blended with vancomycin for hemorrhage control, antibacterial action, and tissue repair in infected trauma wounds.Materials today. Bio · 2021Article
- Limited Treatment Options for Diabetic Wounds: Barriers to Clinical Translation Despite Therapeutic Success in Murine Models.Advances in wound care · 2021Article
- The effects of dietary/herbal supplements and the serum levels of micronutrients on the healing of diabetic foot ulcers in animal and human models: a systematic review.Journal of diabetes and metabolic disorders · 2021Review
- Angelica Dahurica Regulated the Polarization of Macrophages and Accelerated Wound Healing in Diabetes: A Network Pharmacology Study andFrontiers in pharmacology · 2021Article
- KGF-2 and FGF-21 poloxamer 407 hydrogel coordinates inflammation and proliferation homeostasis to enhance wound repair of scalded skin in diabetic rats.BMJ open diabetes research & care · 2020Article
- Simultaneous Activation of Erk1/2 and Akt Signaling is Critical for Formononetin-Induced Promotion of Endothelial Function.Frontiers in pharmacology · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Abnormal angiogenesis plays an important role in impaired wound healing and development of chronic wounds in diabetes mellitus. Angelica dahurica radix is a common traditional Chinese medicine with wide spectrum medicinal effects. In this study, we analyzed the potential roles of Angelica dahurica ethanolic extract (ADEE) in correcting impaired angiogenesis and delayed wound healing in diabetes by using streptozotocin-induced diabetic rats. ADEE treatment accelerated diabetic wound healing through inducing angiogenesis and granulation tissue formation. The angiogenic property of ADEE was subsequently verified ex vivo using aortic ring assays. Furthermore, we investigated the in vitro angiogenic activity of ADEE and its underlying mechanisms using human umbilical vein endothelial cells. ADEE treatment induced HUVECs proliferation, migration, and tube formation, which are typical phenomena of angiogenesis, in dose-dependent manners. These effects were associated with activation of angiogenic signal modulators, including extracellular signal-regulated kinase 1/2 (ERK1/2), Akt, endothelial nitric oxide synthase (eNOS) as well as increased NO production, and independent of affecting VEGF expression. ADEE-induced angiogenic events were inhibited by the MEK inhibitor PD98059, the PI3K inhibitor Wortmannin, and the eNOS inhibitor L-NAME. Our findings highlight an angiogenic role of ADEE and its ability to protect against impaired wound healing, which may be developed as a promising therapy for impaired angiogenesis and delayed wound healing in diabetes.
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