ArticlePloS one2017
Performance in eyeblink conditioning is age and sex dependent.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- C/T Ratios in Human Eyeblink Conditioning Paradigms to Examine Cerebellar Function and ADHD: A Narrative Review.Behavioral sciences (Basel, Switzerland) · 2026Review
- Cerebellar Purkinje cell firing reduction contributes to aging-related declining motor coordination in mice.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Training on multiple days results in better learning in embedded eyeblink conditioning in young human adults.NPJ science of learning · 2025Article
- Microbiota, parasitic infections and their relationship with nutritional status and neurocognitive functioning in children from Ecuador-Proyecto Guagua: research protocol for a cross-sectional study.Frontiers in public health · 2025Article
- Associative learning via eyeblink conditioning differs by age from infancy to adulthood.Communications psychology · 2024Article
- Neurite density of the hippocampus is associated with trace eyeblink conditioning latency in 4- to 6-year-olds.The European journal of neuroscience · 2024Article
- Acute aerobic exercise enhances associative learning in regular exercisers but not in non-regular exercisers.Frontiers in behavioral neuroscience · 2024Article
- Accessible and reliable neurometric testing in humans using a smartphone platform.Scientific reports · 2023Article
- Effects of working memory load and CS-US intervals on delay eyeblink conditioning.NPJ science of learning · 2023Article
- Delay eyeblink conditioning performance and brain-wide c-Fos expression in male and female mice.Open biology · 2023Article
- Deficits in cerebellum-dependent learning and cerebellar morphology in male and female BTBR autism model mice.NeuroSci · 2022Article
- Enhanced fear limits behavioral flexibility in Shank2-deficient mice.Molecular autism · 2022Article
- A Critical Investigation of Cerebellar Associative Learning in Isolated Dystonia.Movement disorders : official journal of the Movement Disorder Society · 2022Article
- Late component of trigemino-cervical reflex: changes according to age and gender.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Article
- Weak correlations between cerebellar tests.Scientific reports · 2020Article
- Human sleep consolidates allergic responses conditioned to the environmental context of an allergen exposure.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- A New 3-Day Standardized Eyeblink Conditioning Protocol to Assess Extinction Learning From Infancy to Adulthood.Frontiers in behavioral neuroscience · 2020Article
- Sex differences in a rabbit eyeblink conditioning model of PTSD.Neurobiology of learning and memory · 2018Article
- A Longer Interstimulus Interval Yields Better Learning in Adults and Young Adolescents.Frontiers in behavioral neuroscience · 2018Article
- Failure to Find a Conditioned Placebo Analgesic Response.Frontiers in psychology · 2018Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A growing body of evidence suggests that the cerebellum is involved in both cognition and language. Abnormal cerebellar development may contribute to neurodevelopmental disorders such as attention deficit hyperactivity disorder (ADHD), autism, fetal alcohol syndrome, dyslexia, and specific language impairment. Performance in eyeblink conditioning, which depends on the cerebellum, can potentially be used to clarify the neural mechanisms underlying the cerebellar dysfunction in disorders like these. However, we must first understand how the performance develops in children who do not have a disorder. In this study we assessed the performance in eyeblink conditioning in 42 typically developing children between 6 and 11 years old as well as in 26 adults. Older children produced more conditioned eyeblink responses than younger children and adults produced more than children. In addition, females produced more conditioned eyeblink responses than males among both children and adults. These results highlight the importance of considering the influence of age and sex on the performance when studying eyeblink conditioning as a measure of cerebellar development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.