Evidence map›Paper›PMID 28542375›Full record

ArticlePloS one2017

Human plasma metabolomics in age-related macular degeneration (AMD) using nuclear magnetic resonance spectroscopy.

Inês Laíns, Daniela Duarte, António S Barros, Ana Sofia Martins, João Gil, John B Miller, Marco Marques, Tânia Mesquita, Ivana K Kim, Maria da Luz Cachulo and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 2 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.

  1. Pooled it
  2. Metabolomics in Age-Related Macular Degeneration: A Systematic Review.Investigative ophthalmology & visual science · 2020
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 2 countries.

Inês LaínsDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, United States.
Daniela DuarteCICECO- Aveiro Institute of Materials (CICECO/UA), Department of Chemistry, University of Aveiro, Aveiro, Portugal.
António S BarrosCICECO- Aveiro Institute of Materials (CICECO/UA), Department of Chemistry, University of Aveiro, Aveiro, Portugal.
Ana Sofia MartinsCICECO- Aveiro Institute of Materials (CICECO/UA), Department of Chemistry, University of Aveiro, Aveiro, Portugal.
João GilFaculty of Medicine, University of Coimbra (FMUC), Coimbra, Portugal.
John B MillerDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, United States.
Marco MarquesFaculty of Medicine, University of Coimbra (FMUC), Coimbra, Portugal.
Tânia MesquitaAssociation for Innovation and Biomedical Research on Light and Image (AIBILI), Coimbra, Portugal.
Ivana K KimDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, United States.
Maria da Luz CachuloFaculty of Medicine, University of Coimbra (FMUC), Coimbra, Portugal.
Demetrios VavvasDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, United States.
Isabel M CarreiraFaculty of Medicine, University of Coimbra (FMUC), Coimbra, Portugal.
Joaquim N MurtaFaculty of Medicine, University of Coimbra (FMUC), Coimbra, Portugal.
Rufino SilvaFaculty of Medicine, University of Coimbra (FMUC), Coimbra, Portugal.
Joan W MillerDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, United States.
Deeba HusainDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, United States.
Ana M GilCICECO- Aveiro Institute of Materials (CICECO/UA), Department of Chemistry, University of Aveiro, Aveiro, Portugal.ORCID http://orcid.org/0000-0003-3766-4364
Massachusetts Eye and Ear Infirmary · USHospitais da Universidade de Coimbra · PTUniversity of Aveiro · PTAssociation for Innovation and Biomedical Research on Light and Image · PTUniversity of Coimbra · PT

Funding

Necroptosis, neuroprotection and axonal regeneration in retina ganglion cell injuryR01EY025362 · NEI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI VAVVAS, DEMETRIOS · 2015 to 2018
$1.5M
Necroptosis and Neuroprotection in AMDR21EY023079 · NEI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI VAVVAS, DEMETRIOS · 2013 to 2014
$404k
NEI NIH HHS R01 EY025362NEI NIH HHS R21 EY023079
6 · The paper itself

Abstract

purposeTo differentiate the plasma metabolomic profile of patients with age related macular degeneration (AMD) from that of controls, by Nuclear Magnetic Resonance (NMR) spectroscopy.

methodsTwo cohorts (total of 396 subjects) representative of central Portugal and Boston, USA phenotypes were studied. For each cohort, subjects were grouped according to AMD stage (early, intermediate and late). Multivariate analysis of plasma NMR spectra was performed, followed by signal integration and univariate analysis.

resultsSmall changes were detected in the levels of some amino acids, organic acids, dimethyl sulfone and specific lipid moieties, thus providing some biochemical information on the disease. The possible confounding effects of gender, smoking history and age were assessed in each cohort and found to be minimal when compared to that of the disease. A similar observation was noted in relation to age-related comorbidities. Furthermore, partially distinct putative AMD metabolite fingerprints were noted for the two cohorts studied, reflecting the importance of nutritional and other lifestyle habits in determining AMD metabolic response and potential biomarker fingerprints. Notably, some of the metabolite changes detected were noted as potentially differentiating controls from patients diagnosed with early AMD.

conclusionFor the first time, this study showed metabolite changes in the plasma of patients with AMD as compared to controls, using NMR. Geographical origins were seen to affect AMD patients´ metabolic profile and some metabolites were found to be valuable in potentially differentiating controls from early stage AMD patients. Metabolomics has the potential of identifying biomarkers for AMD, and further work in this area is warranted.

Indexed as

MetabolomicsAgedAged, 80 and overCohort StudiesCross-Sectional StudiesFemaleHumansMacular DegenerationMagnetic Resonance SpectroscopyMaleMiddle Aged

Identifiers

PMID28542375
PMCPMC5436712
OpenAlexW2619963968

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.