ArticlePloS one2017
Transcriptome-microRNA analysis of Sarcoptes scabiei and host immune response.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Genomics reveal local skin immune response key to control sarcoptic mange in Iberian ibex (Capra pyrenaica).BMC genomics · 2024Article
- A glimpse into the world of microRNAs and their putative roles in hard ticks.Frontiers in cell and developmental biology · 2024Review
- Co-infection patterns in the ectoparasitic community affecting the Iberian ibex Capra pyrenaica.Parasites & vectors · 2023Article
- Evidence that Transcriptional Alterations inInternational journal of molecular sciences · 2022Article
- Scabies: Epidemiology, Diagnosis, and Treatment.Deutsches Arzteblatt international · 2021Review
- Infection-provoked psoriasis: Induced or aggravated (Review).Experimental and therapeutic medicine · 2021Review
- Pruritus as a Distinctive Feature of Type 2 Inflammation.Vaccines · 2021Review
- Itch in Scabies-What Do We Know?Frontiers in medicine · 2021Review
- Transcriptome Analysis of Host Inflammatory Responses to the Ectoparasitic MiteFrontiers in immunology · 2021Article
- Early immune suppression leads to uncontrolled mite proliferation and potent host inflammatory responses in a porcine model of crusted versus ordinary scabies.PLoS neglected tropical diseases · 2020Article
- Comparative Transcriptomic Analysis of the Pituitary Gland between Cattle Breeds Differing in Growth: Yunling Cattle and Leiqiong Cattle.Animals : an open access journal from MDPI · 2020Article
- An Antibody Persistent and Protective Two rSsCLP-Based Subunit Cocktail Vaccine againstVaccines · 2020Article
- Transcriptome-based analysis of putative allergens of Chorioptes texanus.Parasites & vectors · 2019Article
- Microarray analysis of infectious bronchitis virus infection of chicken primary dendritic cells.BMC genomics · 2019Article
- A chitinase-like protein from Sarcoptes scabiei as a candidate anti-mite vaccine that contributes to immune protection in rabbits.Parasites & vectors · 2018Article
- Serodiagnostic Potential of Alpha-Enolase FromFrontiers in microbiology · 2018Article
- Molecular characteristics and serodiagnostic potential of chitinase-like protein fromOncotarget · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Scabies is a parasitic disease, caused by the mite Sarcoptes scabiei, and is considered one of the top 50 epidemic diseases and one the most common human skin disease, worldwide. Allergic dermatitis, including an intense itch, is a common symptom, however diagnosis is difficult and there is currently no effective vaccine. The goal of this study was to examine the immune interaction mechanism of both S. scabiei and infected hosts. mRNA-seq and microRNA-seq were conducted on the S. scabiei mite and on infected and uninfected hosts. We focused on differential expression of unigenes and microRNAs, as well as the real targets of unigenes in enriched immune signaling pathways. S. scabiei enhanced host immune function and decreased metabolism after infection, while the immune response of the host inhibited S. scabiei proliferation and metabolism signaling pathways. Differentially expressed unigenes of S. scabiei were enriched in the JAK-STAT signaling pathway and the Toll-like receptor signaling pathway. The differential expression analysis indicated that microRNAs of S. scabiei and hosts have major roles in regulating immune interactions between parasites and hosts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.