ArticlePLoS neglected tropical diseases2017
Single-sex infection with female Schistosoma mansoni cercariae mitigates hepatic fibrosis after secondary infection.
Article in PLoS neglected tropical diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- Reassessing Schistosoma worms: the overlooked role in host pathology and disease elimination.Infectious diseases of poverty · 2025Review
- Intra-specific variations in Schistosoma mansoni and their possible contribution to inconsistent virulence and diverse clinical outcomes.PLoS neglected tropical diseases · 2024Article
- Sja-let-7 suppresses the development of liver fibrosis via Schistosoma japonicum extracellular vesicles.PLoS pathogens · 2024Article
- Individually or as a Team-The Immunological Milieu in the Lung Caused by Migrating Single-Sex or Mixed-Sex Larvae ofPathogens (Basel, Switzerland) · 2023Article
- Sja-Let-7 Attenuates Carbon Tetrachloride-Induced Liver Fibrosis in a Mouse Model via Col1α2.Biology · 2023Article
- Bsep/Abcb11 knockout ameliorates Schistosoma mansoni liver pathology by reducing parasite fecundity.Liver international : official journal of the International Association for the Study of the Liver · 2023Article
- Single-sex schistosomiasis: a mini review.Frontiers in immunology · 2023Review
- Unisexual infection withFrontiers in immunology · 2023Article
- Comparative proteome analysis of the tegument of male and female adult Schistosoma mansoni.Scientific reports · 2022Article
- Excretion patterns ofParasitology · 2022Article
- A one-year unisexualFrontiers in immunology · 2022Article
- Sex-Specific Modulation of the Host Transcriptome in the Spleen ofFrontiers in cellular and infection microbiology · 2022Article
- Human serum activates the tegument of female schistosomes and supports recovery from Praziquantel.Parasitology research · 2021Article
- Duplex real-time PCR for sexing Schistosoma japonicum cercariae based on W chromosome-specific genes and its applications.PLoS neglected tropical diseases · 2020Article
- Preventive CTLA-4-Ig Treatment Reduces Hepatic Egg Load and Hepatic Fibrosis inBioMed research international · 2019Article
- Host Defense Versus Immunosuppression: Unisexual Infection With Male or FemaleFrontiers in immunology · 2018Article
- Estrogen Metabolism-Associated CYP2D6 and IL6-174G/C Polymorphisms in Schistosoma haematobium Infection.International journal of molecular sciences · 2017Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInfection with Schistosoma spp. affects more than 258 million people worldwide. Current treatment strategies are mainly based on the anthelmintic Praziquantel, which is effective against adult worms but neither prevents re-infection nor cures severe liver damage. The best long-term strategy to control schistosomiasis may be to develop an immunization. Therefore, we designed a two-step Schistosoma mansoni infection model to study the immune-stimulating effect of a primary infection with either male or female cercariae, measured on the basis of TH1/TH2-response, granuloma size and hepatic fibrosis after a secondary bisexual S. mansoni challenge. METHODOLOGY/PRINCIPLE
findingsAs a first step, mice were infected with exclusively female, exclusively male, or a mixture of male and female S. mansoni cercariae. 11 weeks later they were secondarily infected with male and female S. mansoni cercariae. At week 19, infection burden, granuloma size, collagen deposition, serum cytokine profiles and the expression of inflammatory genes were analyzed. Mice initially infected with female S. mansoni cercariae displayed smaller hepatic granulomas, livers and spleens, less hepatic fibrosis and higher expression of Ctla4. In contrast, a prior infection with male or male and female S. mansoni did not mitigate disease progression after a bisexual challenge. CONCLUSIONS/SIGNIFICANCE: Our findings provide evidence that an immunization against S. mansoni is achievable by exploiting gender-specific differences between schistosomes.
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Registered trials
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