ArticlePLoS genetics2017
Two extended haplotype blocks are associated with adaptation to high altitude habitats in East African honey bees.
Article in PLoS genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed.
- Genome Evolution in Social Insects.Genome biology and evolution · 2026Review
- Similar Habitat Gradients Across Native and Invasive Ranges Elicit Divergent Evolutionary Responses.Ecology and evolution · 2026Article
- The diversity of insecticide target site mutations in Apis mellifera.BMC genomics · 2026Article
- Parallel clines of chromosomal inversion frequencies in seaweed flies are associated with thermal variation.Heredity · 2026Article
- Ancestral and local adaptation contribute to dispersal out of the Qinghai-Tibet Plateau in a bumblebee.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Contrasting whole-genome diversity patterns and adaptation in honeybees from two southern European glacial refugia.iScience · 2026Article
- Putting Structural Variants Into Practice: The Role of Chromosomal Inversions in the Management of Marine Environments.Molecular ecology · 2025Review
- Genetic mapping in the red mason bee implicates ANTSR as an ancient sex-determining locus in bees and ants.PLoS biology · 2025Article
- Genomic Landscape of High-Altitude Adaptation in East African Mountain Honey Bees (Ecology and evolution · 2025Article
- Chromosome level de Novo hybrid assembly of Asian honeybee, Apis cerana Koreana.Scientific reports · 2025Article
- Positive selection on rare variants of IGF1R and BRD4 underlying the cold adaptation of wild boar.Genetics, selection, evolution : GSE · 2025Article
- Unexpectedly low recombination rates and presence of hotspots in termite genomes.Genome research · 2025Article
- Omics in mini-livestock: a genomic perspective on the future of sustainable food systems.Frontiers in genetics · 2025Review
- Accurate Detection ofEcology and evolution · 2024Article
- Article
- Quantifying Abdominal Coloration of Worker Honey Bees.Insects · 2024Article
- Chromosomal Inversions and the Demography of Speciation in Drosophila montana and Drosophila flavomontana.Genome biology and evolution · 2024Article
- Genetic differentiation and local adaptation of the Japanese honeybee,Ecology and evolution · 2023Article
- The impact of geography and climate on the population structure and local adaptation in a wild bee.Evolutionary applications · 2023Article
- AmelHap: Leveraging drone whole-genome sequence data to create a honey bee HapMap.Scientific data · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding the genetic basis of adaption is a central task in biology. Populations of the honey bee Apis mellifera that inhabit the mountain forests of East Africa differ in behavior and morphology from those inhabiting the surrounding lowland savannahs, which likely reflects adaptation to these habitats. We performed whole genome sequencing on 39 samples of highland and lowland bees from two pairs of populations to determine their evolutionary affinities and identify the genetic basis of these putative adaptations. We find that in general, levels of genetic differentiation between highland and lowland populations are very low, consistent with them being a single panmictic population. However, we identify two loci on chromosomes 7 and 9, each several hundred kilobases in length, which exhibit near fixation for different haplotypes between highland and lowland populations. The highland haplotypes at these loci are extremely rare in samples from the rest of the world. Patterns of segregation of genetic variants suggest that recombination between haplotypes at each locus is suppressed, indicating that they comprise independent structural variants. The haplotype on chromosome 7 harbors nearly all octopamine receptor genes in the honey bee genome. These have a role in learning and foraging behavior in honey bees and are strong candidates for adaptation to highland habitats. Molecular analysis of a putative breakpoint indicates that it may disrupt the coding sequence of one of these genes. Divergence between the highland and lowland haplotypes at both loci is extremely high suggesting that they are ancient balanced polymorphisms that greatly predate divergence between the extant honey bee subspecies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.