Evidence map›Paper›PMID 28542142›Full record

ArticleCell death & disease2017

Deletion of Pdcd5 in mice led to the deficiency of placenta development and embryonic lethality.

Ge Li, Chentong Xu, Xin Lin, Liujing Qu, Dan Xia, Beiqi Hongdu, Yan Xia, Xiaokun Wang, Yaxin Lou, Qihua He and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cell death & disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. PDCD5 says no to NO.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  6. CCDC134 serves a crucial role in embryonic development.International journal of molecular medicine · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Ge LiDepartment of Immunology, Peking University School of Basic Medical Science, No. 38 Xueyuan Road, Beijing 100191, China.
Chentong XuDepartment of Immunology, Peking University School of Basic Medical Science, No. 38 Xueyuan Road, Beijing 100191, China.
Xin LinDepartment of Immunology, Peking University School of Basic Medical Science, No. 38 Xueyuan Road, Beijing 100191, China.
Liujing QuDepartment of Immunology, Peking University School of Basic Medical Science, No. 38 Xueyuan Road, Beijing 100191, China.
Dan XiaDepartment of Immunology, Peking University School of Basic Medical Science, No. 38 Xueyuan Road, Beijing 100191, China.
Beiqi HongduDepartment of Immunology, Peking University School of Basic Medical Science, No. 38 Xueyuan Road, Beijing 100191, China.
Yan XiaDepartment of Immunology, Peking University School of Basic Medical Science, No. 38 Xueyuan Road, Beijing 100191, China.
Xiaokun WangCenter for Human Disease Genomics, Peking University, No. 38 Xueyuan Road, Beijing 100191, China.
Yaxin LouMedical and Healthy Analytical Center, Peking University, No. 38 Xueyuan Road, Beijing 100191, China.
Qihua HeMedical and Healthy Analytical Center, Peking University, No. 38 Xueyuan Road, Beijing 100191, China.
Dalong MaDepartment of Immunology, Peking University School of Basic Medical Science, No. 38 Xueyuan Road, Beijing 100191, China.
Yingyu ChenDepartment of Immunology, Peking University School of Basic Medical Science, No. 38 Xueyuan Road, Beijing 100191, China.
Peking University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Programmed cell death 5 (PDCD5) is an apoptosis promoter molecule that displays multiple biological activities. However, the function of PDCD5 in vivo has not yet been investigated. Here, we generated a Pdcd5 knockout mouse model to study the physiological role of PDCD5 in vivo. Knockout of the Pdcd5 gene resulted in embryonic lethality at mid-gestation. Histopathological analysis revealed dysplasia in both the LZs and JZs in Pdcd5

Indexed as

Gene DeletionPlacentationAnimalsApoptosisApoptosis Regulatory ProteinsBiological TransportCell Cycle CheckpointsCell ProliferationEmbryo LossEmbryo, MammalianFemaleFibroblastsHeartHepatocyte Growth FactorLiverMice, Inbred C57BLApoptosis Regulatory ProteinsHepatocyte Growth FactorNeoplasm ProteinsPdcd5 protein, mousePlatelet Endothelial Cell Adhesion Molecule-1Proto-Oncogene Proteins c-aktTOR Serine-Threonine KinasesVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-2

Identifiers

PMID28542142
PMCPMC5520688
OpenAlexW2618830604

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.