Evidence map›Paper›PMID 28542132›Full record

ArticleCell death & disease2017

Inhibition of SDF-1 receptors CXCR4 and CXCR7 attenuates acute pulmonary inflammation via the adenosine A

Franziska Magdalena Konrad, Nadine Meichssner, Annette Bury, Kristian-Christos Ngamsri, Jörg Reutershan

Abstract read
In one paragraph

Article in Cell death & disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Article
  3. Atypical chemokine receptors in the immune system.Nature reviews. Immunology · 2024
    Review
  4. The RNA mCellular & molecular immunology · 2024
    Article
  5. Crosstalk between CD4American journal of respiratory and critical care medicine · 2023
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Role of caveolin-1 in chronic postsurgical pain in rats.Experimental and therapeutic medicine · 2021
    Article
  12. Article
  13. Adenosine and Inflammation: Here, There and Everywhere.International journal of molecular sciences · 2021
    Review
  14. Hyperinflammation and airway surface liquid dehydration in cystic fibrosis: purinergic system as therapeutic target.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2021
    Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Franziska Magdalena KonradDepartment of Anesthesiology and Intensive Care Medicine, University Hospital of Tübingen, Tübingen, Germany.
Nadine MeichssnerDepartment of Anesthesiology and Intensive Care Medicine, University Hospital of Tübingen, Tübingen, Germany.
Annette BuryDepartment of Anesthesiology and Intensive Care Medicine, University Hospital of Tübingen, Tübingen, Germany.
Kristian-Christos NgamsriDepartment of Anesthesiology and Intensive Care Medicine, University Hospital of Tübingen, Tübingen, Germany.
Jörg ReutershanDepartment of Anesthesiology and Intensive Care Medicine, University Hospital of Tübingen, Tübingen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute pulmonary inflammation is characterized by migration of polymorphonuclear neutrophils into the different compartments of the lung. Recent studies showed evidence that the chemokine stromal cell-derived factor (SDF)-1 and its receptors CXCR4 and CXCR7 influence migration of immune cells and their activity was linked to adenosine concentrations. We investigated the particular role of CXCR4- and CXCR7-inhibition and the potential link to the adenosine A

Indexed as

Acute DiseaseAnimalsBenzylaminesBlood CellsCapillary PermeabilityCell MovementChemokine CXCL12CyclamsGene Expression RegulationHematopoiesisHeterocyclic CompoundsHumansLungMaleMice, Inbred C57BLNeutrophilsBenzylaminesChemokine CXCL12Cmkor1 protein, mouseCXCR4 protein, mouseCyclamsHeterocyclic CompoundsplerixaforReceptor, Adenosine A2BReceptors, CXCRReceptors, CXCR4

Identifiers

PMID28542132
PMCPMC5520683

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.